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(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Structure
CAS No.
1883423-59-3
Chemical Name:
(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
Synonyms
CPD1540;MSC2530818;Cyclin dependent kinase,Inhibitor,CDK,MSC2530818,inhibit,MSC 2530818,MSC-2530818;(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone;[(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)methanone;Methanone, [(2S)-2-(4-chlorophenyl)-1-pyrrolidinyl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-
CBNumber:
CB53175818
Molecular Formula:
C18H17ClN4O
Molecular Weight:
340.81
MOL File:
1883423-59-3.mol
Modify Date:
2024/7/2 8:55:11
Request For Quotation

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Properties

Boiling point 576.5±50.0 °C(Predicted)
Density 1.373±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml
form A crystalline solid
pka 9.65±0.40(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
NFPA 704
0
2 0

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Chemical Properties,Uses,Production

Description

MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM). It is selective for Cdk8 over a panel of 264 kinases at 1 μM but does inhibit glycogen synthase kinase 3α (GSK3α; IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an IC50 value of 8 nM. It also inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays). MSC2530818 (50 and 100 mg/kg) reduces tumor growth in a SW620 mouse xenograft model.

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Suppliers

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ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
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Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
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Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
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Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
Career Henan Chemica Co 58
Zhejiang J&C Biological Technology Co.,Limited 58
Labnetwork lnc. 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Shijiazhuang Leather Bureau Chemical Technology Co., Ltd. 58

1883423-59-3((S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone)Related Search:

(R)-2-(4-CHLOROPHENYL)PYRROLIDINE Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl- (2S)-2-(4-CHLOROPHENYL)PYRROLIDINE HCL (2R)-2-(4-CHLOROPHENYL)PYRROLIDINE HCL (S)-2-(4-CHLOROPHENYL)PYRROLIDINE
(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone MSC2530818 CPD1540 [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)methanone Methanone, [(2S)-2-(4-chlorophenyl)-1-pyrrolidinyl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)- Cyclin dependent kinase,Inhibitor,CDK,MSC2530818,inhibit,MSC 2530818,MSC-2530818 1883423-59-3 API