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Benazepril

CAS No.: 86541-75-5

Chemical Name:: Benazepril

Synonyms: Briem;Benapril;Cibacene;Cibcen WS;genazepril;BENAZCPRIL;Cibacen WS;Benazepril;Benazapril;BENAZEPRIL MM

CBNumber:: CB5348020

Molecular Formula:: C24H28N2O5

Molecular Weight:: 424.49

MOL File:: 86541-75-5.mol

Modify Date:: 2024/7/2 8:55:11

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Benazepril Properties

Melting point	148-149°
alpha	D -159° (c = 1.2 in ethanol)
Boiling point	691.2±55.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO
pka	3.73±0.10(Predicted)
form	Solid
color	White to off-white
BCS Class	1
CAS DataBase Reference	86541-75-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25

Benazepril Chemical Properties,Uses,Production

Definition

ChEBI: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzy e inhibitor benazeprilat in the treatment of hypertension and heart failure.

Enzyme inhibitor

This ACE-directed pro-drug (FWfree-acid = 424.50 g/mol; CAS 86541-75-5), also known as 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5- tetrahydro-2-oxo-(S-(R*,R*))-1H-1-benzazepine-1-acetic acid, Lotensin and CGS 14824A, is rapidly metabolized to its diacid benazeprilat (CGS 14831; FWfree-diacid = 396.44 g/mol), the latter a potent, long-acting inhibitor of peptidyl-dipeptidase A, or angiotensin I-converting enzyme, IC50 = 1.7 nM. Lotensin is used to treat hypertension, congestive heart failure, and chronic renal failure. The antihypertensive effects of benazepril begin as early as 30 min after a single dose, and those effects during consecutive dosing are also sustained for 24 h with a lesser diurnal variation in blood pressure

Benazepril Preparation Products And Raw materials

Raw materials

4-Methylmorpholine Cinchonidine Sulfurous Acid 4-Nitrobenzenesulfonyl chloride Tert-butyl ester

Benzyl 2-bromoacetate Sodium azide Ethyl 2-oxo-4-phenylbutyrate Sodium cyanoborohydride

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Preparation Products

Benazepril Suppliers

Global( 148)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Alfa Omega Pharma	+91-8050045945 +91-9972665399	Maharashtra, India	126	58	Inquiry
Euroasia Trans Continental	+91 22 56349035-36	New Delhi, India	519	47	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Excel International	08048957044	Mumbai, India	36	58	Inquiry
Thykn India International	08048372611Ext 128	Mumbai, India	22	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry

Supplier	Advantage
Alfa Omega Pharma	58
Euroasia Trans Continental	47
OCEAN TRADING CORPORATION	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Excel International	58
Thykn India International	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharma Affiliates	58

Benazepril Spectrum

Benazepril(86541-75-5)¹HNMR

86541-75-5(Benazepril)Related Search:

PHENYL VALERATE Phenylhydrazine Glycine 3,4'-DIAMINODIPHENYLMETHANE 1,1'-Carbonyldiimidazole

Propyl gallate Lithium diisopropylamide Propyl butyrate ALTRENOGEST Carbonyl iron powder

S-ATBA Benazepril Related Compound G Benazepril hydrochloride NICKEL CARBONYL Benazepril Related Compound D

Benazepril Related Compound F Hydrocortisone CORTISONE

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2-[(4s)-4-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-6-azabicyclo[5.4.0]undeca-7,9,11-trien-6-yl]acetic acid genazepril BENAZEPRIL HCL, RELATED COMPOUND B(3S)-3-[[(1R)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-2,3,4,5-TETRAHYDRO-2-OXO-1H-1-BENAZAPINE-1-ACETIC ACID, MONOHYDROCHLORIDE USP STANDARD BENAZEPRIL HCL, MM(CRM STANDARD) BENAZEPRIL HCL, USP STANDARD BENAZEPRIL HCL USP(CRM STANDARD) BENAZEPRIL MM BENAZEPRIL MM(CRM STANDARD) BENAZEPRIL FREE BASE BENAZCPRIL 1H-1-Benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)- 1H-1-Benzazepine-1-acetic acid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, [S-(R*,R*)]- Benapril Briem Cibacen WS Cibacene (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid [S-(R^<*>^，R^<*>^)]-3-[[1- (Ethoxycarbonyl)-3-phenylpropyl]amino]-2，3，4，5-tetrahydro-2-oxo-lH-1-benzazepine-1-acetic acid Cibacene：Lotensin 2-[(4S)-4-[[(1S)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-3-oxo-2-azabicyclo[5.4.0]undeca-7,9,11-trien-2-yl]acetic acid (3S)-3-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid 2-[(3S)-3-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-1-yl]acetic acid Cibcen WS Benazepril Benazapril 2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid Benazepril USP/EP/BP 2-((S)-3-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid Bifeprunox Impurity 16 86541-75-5 C24H28N2O5 API Antihypertensive Active Pharmaceutical Ingredients