D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
- CAS No.
- 80938-69-8
- Chemical Name:
- D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
- Synonyms
- PDMP;DL-PDMP;DL-threo-PDMP;D,L-THREO-PDMP HCL;DL-THREO-PDMP, HYDROCHLORIDE;(+/-)-THREO-PDMP HYDROCHLORIDE;DL-threo-PDMP, Hydrochloride;(+)-threo-1-phenyl-2-decanoylamino-3-*morpholino-;(±)-threo-PDMP hydrochloride, PDMP hydrochloride;D,L-threo-PDMP, Glucosylceramide synthase inhibitor
- CBNumber:
- CB5438950
- Molecular Formula:
- C23H39ClN2O3
- Molecular Weight:
- 427.03
- MOL File:
- 80938-69-8.mol
- Modify Date:
- 2025/1/27 9:38:02
| storage temp. | -20°C |
|---|---|
| solubility | DMF: 25 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:5): 0.05 mg/ml |
| form | White solid |
| color | white |
| biological source | synthetic (organic) |
| Water Solubility | water: 50mg/mL, clear, colorless |
D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P7340 | (±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride | 80938-69-8 | 100MG | ₹117537.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 513100 | DL-threo-PDMP, Hydrochloride - CAS 80938-69-8 - Calbiochem PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme. | 80938-69-8 | 50MG | ₹22650 | 2022-06-14 | Buy |
D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Chemical Properties,Uses,Production
Description
DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-threo-(1R,2R)-PDMP and L-threo-(1S,2S)-PDMP. DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 μM. It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro. The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo-(1R,2R) enantiomer. The D-threo-PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100. [Matreya, LLC. Catalog No. 1719]
Uses
DL-threo-PDMP can deplete cells and mice of their glucosphinolipids.
Biochem/physiol Actions
Glucosylceramide synthase inhibitor; blocks formation of glucosylceramide from ceramide.
D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Preparation Products And Raw materials
Raw materials
Preparation Products
D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49734 | 58 | Inquiry |
| Aladdin Scientific | United States | 52924 | 58 | Inquiry | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9803 | 58 | Inquiry |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | China | 11183 | 58 | Inquiry |
| Merck KGaA | 21-20338288 | China | 292394 | 58 | Inquiry |
| Absin Bioscience Inc. | 021-38015121-8802 | CHINA | 6208 | 58 | Inquiry |
| Abcam Limited | +1 (877) 774-8286 | United States | 6001 | 50 | Inquiry |
| SHANGHAI ZZBIO CO., LTD. | 15102117276 19921389125 | China | 12064 | 58 | Inquiry |
| Enzo Biochem Inc | Enzo Biochem Inc. 13797054060 | China | 177174 | 58 | Inquiry |