DO264
- CAS No.
- 2301866-59-9
- Chemical Name:
- DO264
- Synonyms
- DO264;DO264 (DO-264;DO264;DO-264;DO 264;N-[1-[3-Chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinylthiourea;Thiourea, N-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinyl-
- CBNumber:
- CB54844719
- Molecular Formula:
- C23H20Cl2F3N5O2S
- Molecular Weight:
- 558.4
- MOL File:
- 2301866-59-9.mol
- Modify Date:
- 2023/6/8 9:03:01
| Boiling point | 601.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Soluble in DMSO (up to 30 mg/ml). |
| form | solid |
| pka | 11.53±0.70(Predicted) |
| color | Pale yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
DO264 Chemical Properties,Uses,Production
Description
DO264 is an inhibitor of α/β-hydrolase domain-containing protein 12 (ABHD12; IC50 = 11 nM). It inhibits ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells. DO264 increases levels of chemokine (C-C motif) ligand 3 (CCL3), CCL4, TNF-α, and IL-1β in M1-polarized THP-1 macrophages. It potentiates ferroptotic cell death induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in HT1080 fibrosarcoma and SU-DHL-5 B cell lymphoma cells when used at a concentration of 1 μM. In vivo, DO264 (30 mg/kg per day for four weeks) increases levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PS, 1-arachidonoyl-2-hydroxy-sn-glycero-3-PS, 1-docosanoyl-2-hydroxy-sn-glycero-3-PS, 1-stearoyl-2-arachidonoyl-sn-glycero-3-PS, and 1-oleoyl-2-arachidonoyl-sn-glycero-3-PS in mouse brain. It increases levels of CCL2, CCL3, and CCL5 in bronchoalveolar lavage fluid (BALF) and decreases survival in a mouse model of infection with lymphocytic choriomeningitis virus (LCMV) clone 13 when administered at a dose of 30 mg/kg.
Uses
DO264 is a potent inhibitor of ABHD12 (α/β-hydrolase domain-containing 12) which shows negligible interaction with other serine hydrolases as determined by activity-based protein profiling.
DO264 Preparation Products And Raw materials
Raw materials
Preparation Products
DO264 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | China | 4694 | 58 | Inquiry |
| Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | China | 528 | 58 | Inquiry |
| Olix (Shanghai) Pharmaceutical Technology Co., Ltd | 17316404525 | China | 9652 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9282 | 58 | Inquiry |
| Chunchuang (Wuhan) Technology Co., Ltd | 15342225168 | China | 10005 | 58 | Inquiry |