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NADPH

CAS No.: 53-57-6

Chemical Name:: NADPH

Synonyms: NADPN;NADPH;NADPH;NADPH;NADPH2;reduced;Na4 salt;ent-NADPH;β-NADPH-d4;Reduced Co II

CBNumber:: CB5501007

Molecular Formula:: C21H30N7O17P3

Molecular Weight:: 745.42

MOL File:: 53-57-6.mol

MSDS File:: SDS

Modify Date:: 2024/4/29 10:24:55

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NADPH Properties

Boiling point	1175.1±75.0 °C(Predicted)
Density	2.28±0.1 g/cm3(Predicted)
pka	1.13±0.50(Predicted)
EPA Substance Registry System	Nicotinamide adenine dinucleotide phosphate (53-57-6)

NADPH Chemical Properties,Uses,Production

Uses

One of the biologically active forms of nicotinic acid. Differs from NAD by an additional phosphate group at the 2?position of the adenosine moiety. Serves as a coenzyme of hydrogenases and dehydrogenases. Present in living cells primarily in the r

Definition

A coenzyme composed of ribosylnicotinamide 5′- phosphate coupled by pyrophosphate linkage to the 5′-phosphate adenosine 2′,5′-bisphosphate. The reduced from of NADP. It is an energy-storage form that can be transferred to the Calvin cycle where it participates in the production of carbohydrate.

Biological Functions

Nicotinamide adenine dinucleotide phosphate (NADPH) is used to maintain reduced glutathione (GSH) and thioredoxin (TRX). It is also well known as an essential electron donor and an indispensable cofactor for transferring and reserving reduction potential for numerous anabolic reactions. A growing body of evidence has shown that regeneration and maintenance of the cellular NADP(H) content is strongly implicated in various pathological conditions, such as diabetes, cardiovascular disease, neurodegenerative diseases, and aging, especially in tumorigenesis and cancer progression. Compared with non-tumor cells, tumor cells usually maintain high levels of NADPH to power redox defense and use biosynthetic reactions to sustain their rapid growth[1].

Biochem/physiol Actions

NADPH is predominantly bound to intracellular proteins with different affinities. The intracellular content of NADP(H) differs markedly among tissues and cell types. For instance, the total NADP(H) is about 420?nmol/g wet weight in rat liver 59% of total NADP(H) is found in mitochondria, and 30?nmol/g wet weight in skeletal muscle, and the NADPH concentration in the cytosol is 3.1?±?0.3 and 37?±?2?μM in the mitochondrial matrix in HeLa cells. In addition, the redox potentials of the mitochondrial and cytosolic NADP(H) systems are the same, around—400?mV in the liver[1].

References

[1] Huai-Qiang Ju. “NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications.” Signal Transduction and Targeted Therapy (2020): 231.

NADPH Preparation Products And Raw materials

Raw materials

i-Propylcyclopentadienylrhenium tricarbonyl dihydronicotinamide-adenine dinucleotide β-Nicotinamide adenine dinucleotide β-Nicotinamide Mononucleotide Triphosphopyridine nucleotide

Adenosine triphosphate

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Preparation Products

5-amino-2,5-dioxo-pentanoic acid

NADPH Suppliers

Global( 26)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
Maintain Biotech Co., Ltd.	+86-75589664337 +86-15112661142	China	66	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12460	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26368	58	Inquiry
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503259 +86-19930503259	China	18446	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Shanghai daoyang technology co., ltd	询价加3150471267; 13381681725	China	366	58	Inquiry
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 18112977050	China	10529	58	Inquiry
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	China	16168	55	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
CHEMSWORTH	30
Maintain Biotech Co., Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Dideu Industries Group Limited	58
Hebei Guanlang Biotechnology Co., Ltd.	58
LEAPCHEM CO., LTD.	58
Shanghai daoyang technology co., ltd	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	58
Shanghai Macklin Biochemical Co.,Ltd.	55

The brief introduction of NADPH
Reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases are a group of plasma membrane-associated enzymes, among ....
Apr 29，2024

NADPH Spectrum

25 MG -NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED.NA4-SALT AN.GR.(53-57-6)IR1

53-57-6(NADPH)Related Search:

Adenine phosphate salt（1：1） Triphosphopyridine nucleotide

25 MG ?-NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED.NA4-SALT AN.GR. adenosine5’-(trihydrogendiphosphate),2’-(dihydrogenphosphate),p’.fwdarw.5’ -esterwith1,4-dihydro-1-beta-d-ribofuranosyl-3-pyridinecarboxamide dihydronicotinamide-adenine dinucleotide phosphate dihydrotriphosphopyridine nucleotide Adenosine 5-(trihydrogen diphosphate), 2-(dihydrogen phosphate), P?5-ester with 1,4-dihydro-1-.beta.-D-ribofuranosyl-3-pyridinecarboxamide [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methyl [[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate Adenosine 5'-(Trihydrogen Diphosphate) 2'-(Dihydrogen Phosphate) P'-5'-Ester with 1,4-Dihydro-1--D-ribofuranosyl-3-pyridinecarboxamide Dihydrocodehydrogenase II -Nicotinamide-adenine-dinucleotide-phosphoric Acid Triphosphopyridine Nu NADPH2 Reduced Co II Reduced triphosphopyridine nucleotide [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methyl [[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] hydrogen phosphate [[(2R,3S,4R,5R)-5-(3-aminocarbonyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] [(2R,3R,4R,5R)-5-(6-azanylpurin-9-yl)-3-hydroxy-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate Na4 salt reduced 25 MG -NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED.NA4-SALT AN.GR. USP/EP/BP β-NADPH-d4 ent-NADPH NADPN Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'→5'-ester with 1,4-dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide NADPH,NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED β-Nicotinamide adenine dinucleotide phosphate Reduced form NADPH NADPH NADPH 53-57-6 C21H30N7O17P3 Bases & Related Reagents Carbohydrates & Derivatives Nucleotides Phosphorylating and Phosphitylating Agents