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5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester

5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Structure
CAS No.
1246213-34-2
Chemical Name:
5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester
Synonyms
5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester;Benzeneacetic acid, 5-(1,1-dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-, methyl ester;5-?(1,?1-?Dimethylethyl)?-?2-?hydroxy-?α,?α-?dimethyl-?4-?nitro-benzeneacetic Acid Methyl Ester
CBNumber:
CB55990912
Molecular Formula:
C15H21NO5
Molecular Weight:
295.34
MOL File:
1246213-34-2.mol
Modify Date:
2023/4/23 13:52:06
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5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Properties

Boiling point 386.8±42.0 °C(Predicted)
Density 1.166±0.06 g/cm3(Predicted)
solubility Chloroform; Dichloromethane; Methanol
pka 8.01±0.10(Predicted)
form Solid
color Pale Yellow

5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Chemical Properties,Uses,Production

Uses

5-?(1,?1-?Dimethylethyl)?-?2-?hydroxy-?α,?α-?dimethyl-?4-?nitro-benzeneacetic Acid Methyl Ester is an intermediate in synthesizing Ivacaftor Carboxylic Acid (I940605). It is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.

5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Preparation Products And Raw materials

Raw materials

2-BroMo-4-tert-butyl-5-nitro-phenol DIMETHYLKETENE METHYL TRIMETHYLSILYL ACETAL

Preparation Products

5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Suppliers

Global( 2)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Toronto Research Chemicals Inc. +1 (416) 665-9696 Canada 6688 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Supplier Advantage
Toronto Research Chemicals Inc. 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Benzeneacetic acid, 5-(1,1-dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-, methyl ester 5-?(1,?1-?Dimethylethyl)?-?2-?hydroxy-?α,?α-?dimethyl-?4-?nitro-benzeneacetic Acid Methyl Ester 1246213-34-2