DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE)
- CAS No.
- 85272-30-6
- Chemical Name:
- DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE)
- Synonyms
- DK412;diisopropylbis(trifluoromethanesulfonyl)silane;DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE);Diisopropylsilylenebis(trifluoromethanesulfonate);TRIFLUOROMETHANESULFONIC ACID DIISOPROPYLSILYLENE ESTER;DIISOPROPYLSILYL BIS(TRIFLUOROMETHANE-SU LFONATE), TECH.;Bis(trifluoromethanesulfonic acid)diisopropylsilanediyl ester;Bis(1-methylethyl)[[(trifluoromethyl)sulfonyl]oxy]silyl triflate;Methanesulfonic acid, trifluoro-, bis(1-methylethyl)silylene ester;Methanesulfonic acid, 1,1,1-trifluoro-, bis(1-methylethyl)[[(trifluoromethyl)sulfonyl]oxy]silyl ester
- CBNumber:
- CB5678556
- Molecular Formula:
- C8H14F6O6S2Si
- Molecular Weight:
- 412.4
- MOL File:
- 85272-30-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/7 8:28:39
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 |
| Hazard Codes | C |
| Risk Statements | 34-37 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| F | 10-21 |
| HazardClass | 8 |
| PackingGroup | III |
DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 375942 | Diisopropylsilyl bis(trifluoromethanesulfonate) 96% | 85272-30-6 | 5G | ₹6070 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 375942 | Diisopropylsilyl bis(trifluoromethanesulfonate) 96% | 85272-30-6 | 25G | ₹53960 | 2022-06-14 | Buy |
DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Chemical Properties,Uses,Production
Physical properties
bp 85–86°C/2mmHg;d 1.396 g cm?3; fp 110°C.
Uses
Diisopropylsilyl
bis(trifluoromethanesulfonate) has more recently been
used to prepare diisopropylsilyl-linked oligonucleotide analogs.
Silylation of 5'-O-(dimethoxytrityl)-2'-deoxynucleosides using
diisopropylsilyl bis(trifluoromethanesulfonate) and the hindered
base 2,6-di-t-butyl-4-methylpyridine (Dtbp) provided quantitative
yield of 3'-O-diisopropylsilanols (eq 2). Hence, silylation
of 5'-O-(dimethoxytrityl)thymidine, N6-benzoyl-2'-deoxy-5'-O-
(dimethoxytrityl)adenosine, N4-benzoyl-2'-deoxy-5'-O-(dimethoxytrityl)
cytidine, and N2-isobutyryl-2'-deoxy-5'-O-(dimethoxytrityl)
guanosine gave the desired products 5a–d in excellent
yields.
Coupling of products 5a–d with unprotected thymidine
resulted in formation of 3',5'-linked dinucleosides 6a–d selectively,
and the dimer 7 from reaction with secondary hydroxyl
group of thymidine was not observed (eq 3). Subsequent silylation
and coupling with another molecule of thymidine gave 3,5-
linked trinucleoside 8 in 76% yield (eq 4). A tetrathymidylate oligomer was prepared by 3'-O-silylation of 8 followed by
coupling with thymidine. Although no self-condensation was
observed, only 30% of the product 9 was obtained after purification
by preparative HPLC.
Preparation
conveniently prepared by the slow addition of 2 equiv of trifluoromethanesulfonic acid to a stirring mixture of chlorodiisopropylsilane, followed by direct distillation of the product from the reaction flask to yield the product as a pale yellow oil.
DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18628 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29821 | 58 | Inquiry |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13182 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Junwee Chemical co., Ltd. | +86-571-85808636 +86-13958122542 | China | 821 | 58 | Inquiry |
| Shanghai Zhuangming Biopharma Co., Ltd. | +86-19189228086 +86-18858568638 | China | 629 | 58 | Inquiry |
| Zhuangming New Material Technology Jiangsu Co., Ltd. | 0513-86936896 17312398916 | China | 507 | 58 | Inquiry |