(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE
- CAS No.
- 6989-98-6
- Chemical Name:
- (+)-TUBOCURARINE CHLORIDE PENTAHYDRATE
- Synonyms
- TUBOCURARINE CHLORIDE;Tubarine pentahydrate.;Tubocurarin-dichloride;TUBOCURARINE CHLORIDE 98%;Tubocurarine hydroehloride;Tubocurarine Chloride (250 mg);Tubocurarine Chloride (1702008);Tubocurarine chloride,98.0-102.0%;Tubocurarin-dichloride, Pentahydrat;TubocurarineChloridePentahydrate>
- CBNumber:
- CB5737132
- Molecular Formula:
- C37H44Cl2N2O7
- Molecular Weight:
- 699.67
- MOL File:
- 6989-98-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:15
| Melting point | 275-280 °C (dec.)(lit.) |
|---|---|
| Density | 1.2074 (rough estimate) |
| refractive index | 193 ° (C=1, H2O) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow |
| form | Crystalline powder |
| color | White to Light yellow to Light orange |
| optical activity | [α]20/D +195±5°, c = 0.5% in H2O |
| Water Solubility | Soluble in water to 50mg/ml, with warming as needed. Also soluble in ethanol or methanol |
| Sensitive | Air Sensitive |
| Merck | 14,9807 |
| BRN | 3896374 |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310+P330-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45-36/37/39-22 | |||||||||
| RIDADR | UN 1544 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YO5100000 | |||||||||
| F | 10-23 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T2379 | Tubocurarine hydrochloride pentahydrate ≥97% | 6989-98-6 | 100MG | ₹9212.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 93750 | (+)-Tubocurarine chloride pentahydrate ≥97.0% (TLC) | 6989-98-6 | 250MG | ₹9742.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 93750 | (+)-Tubocurarine chloride pentahydrate ≥97.0% (TLC) | 6989-98-6 | 1G | ₹32648.2 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C0433 | Tubocurarine Chloride Pentahydrate | 6989-98-6 | 100MG | ₹4000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0433 | Tubocurarine Chloride Pentahydrate | 6989-98-6 | 1G | ₹29600 | 2022-05-26 | Buy |
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE Chemical Properties,Uses,Production
Description
Tubocurarine chloride is the only naturally occurring neuromuscular blocking agent. It is derived from the bark of the South American plant chondrodendron tomentosum, which has been used for centuries by South American Indians as an arrow poison. I t was the first non-depolarising neuromuscular blocking agent to be used in humans. I t has a marked propensity to produce histamine release and thus hypotension, with possibly a compensatory tachycardia. Historically, tubocurarine, alcuronium and gallamine have been used in clinical practice, but they are no longer available in the UK. A lcuronium chloride is a semisynthetic derivative of toxiferin, an alkaloid of calabash curare. Gallamine triethiodide is a trisquaternary amine. It was first used in France in 1948. The only recent use of gallamine in the UK was as a small pretreatment dose (10 mg) before suxamethonium.
Chemical Properties
white to slightly yellowish powder
Uses
antibacterial
General Description
Tubocurarine chloride,( )-tubocurarine chloride hydrochloride pentahydrate, isprepared from crude curare by a process of purification andcrystallization. Tubocurarine chloride occurs as a white oryellowish white to grayish white, odorless, crystalline powderthat is soluble in water. Aqueous solutions of it are stableto heat sterilization.
The structural formula for (+)-tubocurarine was longthought to be that of Ia (see structure diagram). Throughthe work of Everett et al.,the structure is now knownto be that of Ib. The monoquaternary nature of Ib thusrevealed has caused some reassessment of thinking concerningthe theoretical basis for the blocking action, becauseall had previously assumed a diquaternary structure(i.e., Ia). Nevertheless, this does not negate the earlierconclusions that a diquaternary nature of the molecule provides better blocking action than does a monoquaternarynature (e.g., Ib is approximately fourfold lesspotent than dimethyl tubocurarine iodide). Further, (+)-isotubocurarine chloride (Ic) has twice the activity of Ib inthe particular test used.
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE Preparation Products And Raw materials
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
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| Alfa Chemistry | United States | 2344 | 58 | Inquiry | |
| Bio Connect Life Sciences | United States | 261 | 58 | Inquiry | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |