Foscarnet
- CAS No.
- 4428-95-9
- Chemical Name:
- Foscarnet
- Synonyms
- C06456;Foscamet;Foscarmet;Phosphonoformate;Phosphonoformic acid;Carboxyphosphonic acid;Dihydroxyoxophosphinecarboxylic acid;Phosphinecarboxylic acid, 1,1-dihydroxy-, 1-oxide
- CBNumber:
- CB61104903
- Molecular Formula:
- CH3O5P
- Molecular Weight:
- 126.01
- MOL File:
- 4428-95-9.mol
- Modify Date:
- 2022/12/21 16:56:50
Foscarnet Chemical Properties,Uses,Production
Definition
ChEBI: Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to bl ndness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
Enzyme inhibitor
This pyrophosphate analogue (FWtrisodium salt = 191.95 g/mol; CAS 4428-95- 9), also called foscarnet, exhibits antiherpetic activity. It is a stro+ng inhibitor of viral reverse transcriptases and viral replication as well as Na/phosphate cotransporters. Target (s) : adenylyl cyclase; avian myeloblastosis virus reverse transcriptase; cytomegalovirus DNA polymerase (4-6); DNA- directed DNA polymerase; DNA polymerase b; DNA polymerases, viral; duck hepatitis B virus reverse transcriptase ; Epstein-Barr virus DNA polymerase; equine infectious anemia virus reverse transcriptase; exoribonuclease H; feline immunodeficiency virus reverse transcriptase; geranyl-diphosphate cyclase, or bornyl-diphosphate synthase; guanylyl cyclase; HIV-1 reverse transcriptase; human T-lymphotropic virus type III reverse transcriptase; herpes virus reverse transcriptase ; human hepatitis B virus reverse transcripta+se; Moloney murine leukemia virus reverse transcriptase; Na-dependent phosphate transport (32-38); phosphoenolpyruvate carboxylase; phosphoenolpyruvate mutase; phosphonoacetate hydrolase; phosphonopyruvate hydrolase; ribonuclease H; RNA-directed DNA polymerase; simian immunodeficiency virus reverse transcriptase; and woodchuck hepatitis virus reverse transcriptase.
Foscarnet Preparation Products And Raw materials
Foscarnet Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Service Chemical Inc. | 888-895-6920 | Germany | 6373 | 71 | Inquiry |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | China | 17995 | 56 | Inquiry |
| BOC Sciences | 1-631-485-4226; 16314854226 | United States | 14059 | 65 | Inquiry |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | China | 54986 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Service Chemical Inc. | 71 |
| ChemStrong Scientific Co.,Ltd | 56 |
| BOC Sciences | 65 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 58 |