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Bromocriptine

CAS No.: 25614-03-3

Chemical Name:: Bromocriptine

Synonyms: Parlodel;bromoergocryptine;BROMOCRITINE;bromocryptine;2-bromo-ergocryptin;Kripton;SAN 15-754;bromocriptin;,6’,18-trione;BROMOCRIPTINE

CBNumber:: CB6136426

Molecular Formula:: C32H40BrN5O5

Molecular Weight:: 654.59

MOL File:: 25614-03-3.mol

Modify Date:: 2024/5/15 13:45:27

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Bromocriptine Properties

Melting point	215-218° (dec)
alpha	D20 -195° (c = 1 in methylene chloride)
Boiling point	891.3±65.0 °C(Predicted)
Density	1.2734 (rough estimate)
refractive index	1.6400 (estimate)
pka	pKa 4.90±0.05(80% MCS t = RT) (Uncertain)
Water Solubility	2.07mg/L(temperature not stated)
CAS DataBase Reference	25614-03-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Warning
Hazard statements	H361-H362-H302
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P201-P260-P263-P264-P270-P308+P313
Toxicity	An ergot alkaloid derivative that exhibits potent dopamine agonist properties, particularly at D2 dopamine receptors. Bromocriptine, like dopamine, inhibits prolactin release from the pituitary and so is used in endocrine disorders, such as hyperprolactinemia. It is also used in the treatment of Parkinson’s disease. A large “first-pass” effect is seen with bromocriptine, and peak concentrations occur about 1.5-3 h after ingestion, with a half-life of about 3 h. Nausea, vomiting, and orthostatic hypotension are among the acute adverse effects. Long-term use has been associated with dyskinesias, constipation, psychoses, digital spasm, and erythromelalgia. The LD50 in rabbits exceeds 1 g/kg, p.o., and 12 mg/kg, i.v.

Bromocriptine Chemical Properties,Uses,Production

Chemical Properties

Crystals.

Uses

Bromocriptine, a dopaminomimetic that is a dopamine D2 receptor agonist, possesses expressed antiparkinsonian activity. It is used for treating all phases of idiopathic and postencephalic Parkinsonism.

Definition

An semisynthetic ergotamine alkaloid derivative and powerful dopamine D2 agonist. It inhibits prolactin secretion and release from the pituitary and retards tumor growth.

World Health Organization (WHO)

Bromocriptine, a semisynthetic ergot alkaloid derivative and prolactin inhibitor was introduced into medicine in 1976. It is used in the prevention of lactation, but because of the risk of rebound effect and since only 10% of women benefit therapeutically from such intervention, the United States Food and Drug Administration has requested manufacturers to no longer indicate preparations containing bromocriptine for this purpose. The World Health Organization is not aware of similar action having been taken elsewhere.

Hazard

Poison; teratogen; developmental abnor- malities of the respiratory system,musculoskeletal system, rogenital system, craniofacial area, and body wall; teratogen; mutagen; questionable car- cinogen; tumorigen; causes nausea, vomiting, orthostatic hypotension; constipation, dyskinesias, psychoses, digital spasm, erythromelalgia.

Mechanism of action

Bromocriptine is absorbed after oral administration, but approximately 90% of a dose undergoes extensive first-pass hepatic metabolism, with the remainder hydrolyzed in the liver to inactive metabolites that are eliminated mostly in the bile. The half-life is relatively short (~3 hours).

Clinical Use

Bromocriptine is an ergot peptide derivative that is a partial agonist at D1-type and a full agonist at D2-type postsynaptic dopamine receptors, usually given in combination with levodopa therapy. It was the first direct dopamine receptor agonist used in treatment of Parkinson's disease after its development as an inhibitor of prolactin release (via activation of anterior pituitary D2 receptors). At low doses (typically 1–5 mg/day), bromocriptine is an effective prolactin inhibitor, and at higher doses (typically 10–20 mg/day), the antiparkinsonism and mood-elevating effects of bromocriptine become apparent.

Side effects

Bromocriptine has a number of undesirable side effects, even causing mental disturbances in long-term use.

Bromocriptine Preparation Products And Raw materials

Raw materials

Imine BROMOSUCCINIC ACID ALPHA-ERGOCRYPTINE N-Bromosuccinimide

Preparation Products

Bromocriptine Suppliers

Global( 71)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	6011	58	Inquiry
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	China	973	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry
Shanghai Longyu Biotechnology Co., Ltd.	+8613917842738	China	2534	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	China	2255	58	Inquiry
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	China	3149	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharma Affiliates	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
hebei hongtan Biotechnology Co., Ltd	58
career henan chemical co	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
Xi'an MC Biotech, Co., Ltd.	58
Dorne Chemical Technology co. LTD	58

25614-03-3(Bromocriptine)Related Search:

Allyl bromide 3-Bromoanisole 3-Bromopropyne CHLOROPHOSPHONAZO III ALPHA-ERGOCRYPTINE

Cyclopropyl bromide Bromocriptine mesylate EP,(+)-BROMOCRIPTINE MESYLATE,BROMOCRIPTINE MESYLATE,(+)-BROMOCRIPTINE METHANESULFONATE,BROMOCRIPTINE METHANESULPHONATE 2-Bromopropane BroMocriptine IMpurity E Ergoline-8-carboxylic acid, 2-bromo-9,10-didehydro-6-methyl-, (8β)-

BroMocriptine IMpurity F BroMocriptine-13C-d3 BroMocriptine IMpurity G Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (2'β,5'α,8α)- (9CI) 5'alpha(S)-sec-butyl-12'-hydroxy-2'-isopropylergotaman-3',6',18-trione

(8S)-2-BroMo α-Ergocryptine Bromocriptine Impurity A (Mixture of Diastereomers) Bromocriptine Impurity 2

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(5’-alpha)-ropyl) ,6’,18-trione 2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-alpha-(2-methylpropyl)ergotamin-3’ 2-bromo-alpha-ergocryptine 2-bromo-alpha-ergokryptin 2-bromo-alpha-ergokryptine 2-bromoergocryptine alpha-bromoergocriptine bromergocryptine bromocriptin bromoergocriptine ergotaman-3’,6’,18-trione,2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-(2-methylp (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione Kripton BROMOCRIPTINE Bromoergocryptine mesylate 2-Bromo-α-ergokryptine bromocripitine Ergocryptine, 2-bromo- (8CI) 2-Bromo-α-ergokryptin ErgotaMan-3',6',18-trione,2-broMo-12'-hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)-, (5'a)- (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-ergotaman-3',6',18-trione Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'α)- SAN 15-754 Sandoz 15-754 Bromocriptine\n\nDiscontinued, B682600 BromocriptineQ: What is Bromocriptine Q: What is the CAS Number of Bromocriptine Q: What is the storage condition of Bromocriptine Q: What are the applications of Bromocriptine Bromocriptine USP/EP/BP 2-bromo-ergocryptin bromocryptine bromoergocryptine Parlodel BROMOCRITINE 25614-03-3 25614-03-2 C32H40BrN5O5 Organics