FLURAZEPAM
- CAS No.
- 17617-23-1
- Chemical Name:
- FLURAZEPAM
- Synonyms
- D00329;Felmane;Noctosom;dalmane-r;ro56901/3;Ro 56901/3;Stauroderm;FLURAZEPAM;ro-5-6901/3;Insumin (tn)
- CBNumber:
- CB6157449
- Molecular Formula:
- C21H23ClFN3O
- Molecular Weight:
- 387.88
- MOL File:
- 17617-23-1.mol
- Modify Date:
- 2024/3/14 15:18:27
| Melting point | 77-82° |
|---|---|
| Boiling point | 551.4±50.0 °C(Predicted) |
| Density | 1.2089 (estimate) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <6 mg/mL |
| pka | pKa 1.90±0.05(H2O) (Uncertain);8.16±0.05 (Uncertain) |
| form | solid |
| color | light yellow |
| EPA Substance Registry System | 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro- (17617-23-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P260-P301+P310-P311 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-33-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 1/2-22-36-45-36/37-16-7 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DF0875000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
FLURAZEPAM Chemical Properties,Uses,Production
Description
Flurazepam (CRM) (Item No. 18160) is a certified reference material that is structurally categorized as a benzodiazepine. It acts as a partial agonist of the benzodiazepine site on GABAA receptors, potentiating the action of GABA with an EC50 value of 930 nM in neuronal chick spinal cord cultures. Through this signaling mechanism, flurazepam produces anxiolytic and sedative properties that have been implemented clinically in the treatment of insomnia but also carry a potential for misuse. This product is intended for forensic and research purposes.
Chemical Properties
Flurazepam is a pale yellow crystalline solid.
Uses
Anticonvulsant; relaxant (muscle); sedative-hypnotic Dalmane (Valeant.
Pharmacokinetics
Chlorazepate is yet another benzodiazepine that is rapidly metabolized (3-decarboxylation) to N-desmethyldiazepam and so shares similar clinical and pharmacokinetic properties to chlordiazepoxide and diazepam.
Side effects
The half-life of flurazepam is fairly long (~7 hours); consequently, it has the same potential as chlordiazepoxide and diazepam to produce cumulative clinical effects and side effects (e.g., excessive sedation) and residual pharmacological activity, even after discontinuation.
Safety Profile
Poison by intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Caution: May be habit forming. This is a controlled substance (depressant) listed in the US. Code of Federal Regulations, Title 21 Part 1308.14. When heated to decomposition it emits very toxic fumes of Cl-, Fand NOx. See also DIAZEPAM.
Potential Exposure
A Drug. Flurazepam is used as a seda tive in capsules or liquid form.
Metabolism
Flurazepam is administered orally as the dihydrochloride salt. It is rapidly 1N-dealkylated to give the 2′-fluoro derivative of N-desmethyldiazepam, and it subsequently follows the same metabolic pathways as chlordiazepoxide and diazepam.
Shipping
UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Waste Disposal
It is inappropriate and possi bly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quanti ties of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
FLURAZEPAM Preparation Products And Raw materials
Raw materials
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