Vortioxetine
- CAS No.
- 508233-74-7
- Chemical Name:
- Vortioxetine
- Synonyms
- 1-(2-((2,4-DiMethylphenyl)thio)phenyl)piperazine;Vortioxetin;Votigetin;Votexetine;Lu AA 21004;Vortioxetine;Vortioxetine,98%;1-(2-((2,4-DimethyL;Vortioxetine, >=99%;Vortioxetine USP/EP/BP
- CBNumber:
- CB62614395
- Molecular Formula:
- C18H22N2S
- Molecular Weight:
- 298.45
- MOL File:
- 508233-74-7.mol
- Modify Date:
- 2024/5/13 18:00:15
| Melting point | 115-117°C |
|---|---|
| Boiling point | 424.8±45.0 °C(Predicted) |
| Density | 1.16 |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 8.85±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3 |
| InChIKey | YQNWZWMKLDQSAC-UHFFFAOYSA-N |
| SMILES | N1(C2=CC=CC=C2SC2=CC=C(C)C=C2C)CCNCC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H371-H373-H361 |
| Precautionary statements | P260-P314-P501-P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P309+P311-P405-P501 |
Vortioxetine Chemical Properties,Uses,Production
Description
In September 2013, vortioxetine (also known as Lu AA21004) was approved in the United States for the treatment of major depressive disorder (MDD). Vortioxetine was discovered from a designed multiple ligand approach to identifying an antidepressant agent that combined SERT inhibition with 5-HT1A agonism to more rapidly desensitize 5-HT1A receptors and 5-HT3A antagonism to improve mood and cognitive function. Vortioxetine has a human SERT IC50=5.4 nM, an EC50=200 nM as a human 5-HT1A receptor agonist (efficacy=96%; Ki=39 nM), and an IC50=12 nM as a human 5-HT3A receptor antagonist (Ki=3.7 nM). It has weak inhibition of the dopamine and norepinephrine transporters, but high affinity for the human β1-noradrenergic receptor (Ki=46 nM), human 5-HT1B receptor (Ki=33 nM, partial agonist), and the human 5-HT-7 receptor (Ki=19 nM, antagonist).
Uses
Vortioxetine can be used in biological study of effectiveness of long term vortioxetine treatment of patients with major depressive disorder.
Definition
ChEBI: An N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder.
Synthesis
The sequence involves iterative palladium-catalyzed carbon¨C heteroatom bond formations, the first establishing the thioethereal bond between commercially available thiol (213) and o-iodobromobenzene (214) employing conditions described by Schopfer and Schlapbach. Next, Buchwald¨CHartwig conditions were employed to establish the piperazine linkage, and this was followed by subjection to warm hydrobromic acid to furnish vortioxetine hydrobromide (XXVI) in 75% yield across the entire three-step sequence.
Vortioxetine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| Exemed Pharmaceuticals (Oneiro Chemicals Pvt Ltd) | +91-9687684674 +91-9099061028 | Gujarat, India | 30 | 58 | Inquiry |
| Aktinos Pharma Pvt Ltd | +91-4048541177 +91-4048541177 | Telangana, India | 42 | 58 | Inquiry |
| Aspen Biopharma Labs Pvt Ltd | +91-9248058660 +91-9248058662 | Telangana, India | 234 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Related articles
- The performance of vortioxetine
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- Jan 13，2022
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