ChemicalBook > Product Catalog >Organic Chemistry >Organosulfur compounds >N-Methyl-N-isopropylsulfamoyl amide

N-Methyl-N-isopropylsulfamoyl amide

N-Methyl-N-isopropylsulfamoyl amide Structure
CAS No.
372136-76-0
Chemical Name:
N-Methyl-N-isopropylsulfamoyl amide
Synonyms
METHYL ISO PROPYL SULFAMIDE;N-isopropyl-N-methylsulfamide;N-Methyl-N-isopropylsulfamide;2-[methyl(sulfamoyl)amino]propane;N-Methyl-N-isopropylsulfamoyl amide;[METHYL(PROPAN-2-YL)SULFAMOYL]AMINE;N-Methyl-N-(1-methylethyl)sulfamide;SulfaMide, N-Methyl-N-(1-Methylethyl)-;N-methyl-N-(1-methylethyl)aminosulfonamide
CBNumber:
CB62659701
Molecular Formula:
C4H12N2O2S
Molecular Weight:
152.22
MOL File:
372136-76-0.mol
Modify Date:
2024/6/4 11:20:24

N-Methyl-N-isopropylsulfamoyl amide Properties

Boiling point 238.7±23.0 °C(Predicted)
Density 1.199±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Acetone; Dichloromethane; Methanol
form Solid
pka 12.40±0.60(Predicted)
color White
InChI InChI=1S/C4H12N2O2S/c1-4(2)6(3)9(5,7)8/h4H,1-3H3,(H2,5,7,8)
InChIKey PJNPCKSPJXQBHH-UHFFFAOYSA-N
SMILES S(N(C)C(C)C)(N)(=O)=O

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

N-Methyl-N-isopropylsulfamoyl amide Chemical Properties,Uses,Production

Uses

N-Isopropyl-N-methylsulfamide is an intermediate in the synthesis of unlabeled Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.

Synthesis

Add 160g of ethanol to a 500ml four-necked flask, stir and cool to -5℃. Then, pass 18g (1.06mol) of ammonia gas, control the temperature at -5~0℃ and add 40g (0.23mol) of N-methyl-N-isopropylaminosulfonyl chloride at 0℃. After the addition is completed, keep warm for 1 hour, then control the vacuum of the reaction solution to -0.07MPa, the water bath temperature to 40℃, and concentrate under reduced pressure to dry solid. Add the solid to 120g of dichloromethane, stir at room temperature for 30 minutes to dissolve, and filter to obtain the filtrate. The filtrate is concentrated to dryness under reduced pressure at -0.07MPa and water bath temperature at 40℃ to obtain 33.7g of the product N-Methyl-N-isopropylsulfamoyl amide (HPLC purity 98.2%, yield 95%).

N-Methyl-N-isopropylsulfamoyl amide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-N-isopropylsulfamoyl amide Suppliers

Global( 48)Suppliers
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SHUBH LIFECARE +91-9328040211 +91-9909086363 Gujarat, India 24 58 Inquiry
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Amadis Chemical Company Limited 571-89925085 China 131957 58 Inquiry
Zhengzhou HongSheng Pharmaceutical Co., Ltd. 0371-13526885213 15637198702 China 3988 58 Inquiry
Zhengzhou anmousse chemical products co. LTD 0371-55289822 18737195735 China 7114 58 Inquiry
SulfaMide, N-Methyl-N-(1-Methylethyl)- N-isopropyl-N-methylsulfamide N-Methyl-N-isopropylsulfamoyl amide N-methyl-N-(1-methylethyl)aminosulfonamide [METHYL(PROPAN-2-YL)SULFAMOYL]AMINE 2-[methyl(sulfamoyl)amino]propane N-Methyl-N-isopropylsulfamide N-Methyl-N-(1-methylethyl)sulfamide METHYL ISO PROPYL SULFAMIDE 372136-76-0