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MonoMethylauristatin F

CAS No.: 745017-94-1

Chemical Name:: MonoMethylauristatin F

Synonyms: MMAF;MonoMethylauristatin;F(MMAF);Tacrinum;745017-97-1;Methyloratatin F;MonoMethylauristatin F;Thiazole,2-bromo-6-methyl-;MMAF (MonoMethylauristatin F);MonoMethyl Auristatin F | MMAF

CBNumber:: CB62667922

Molecular Formula:: C39H65N5O8

Molecular Weight:: 731.96

MOL File:: 745017-94-1.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:13

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MonoMethylauristatin F Properties

Boiling point	896.8±65.0 °C(Predicted)
Density	1.116±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in DMSO
form	A solid
pka	3.56±0.10(Predicted)
color	White to off-white
Stability	Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

MonoMethylauristatin F Chemical Properties,Uses,Production

Description

MMAF (Monomethylauristatin F) is an effective tubulin polymerization inhibitor, used as an anti-tumor drug. MMAF (Monomethylauristatin F) is widely used as the cytotoxic component of antibody-conjugated drugs (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A.

Biological Activity

MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A.

Biotechnological Applications

MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

MonoMethylauristatin F Preparation Products And Raw materials

Raw materials

L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl- L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester

Preparation Products

MonoMethylauristatin F Suppliers

Global( 200)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21675	55	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9338	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29900	58	Inquiry
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	China	7287	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	China	5738	58	Inquiry

Supplier	Advantage
Fuxin Pharmaceutical	58
Alpha Biopharmaceuticals Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58

MonoMethylauristatin F Spectrum

MonoMethylauristatin F(745017-94-1)¹HNMR

745017-94-1(MonoMethylauristatin F)Related Search:

Fr 1,1,1-Trichlorotrifluoroethane L-Phenylalanine 2,6-Di-tert-butyl-4-(dimethylaminomethyl)phenol F4

(2R,3R)-N-((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)-3-Methoxy-2-Methyl-3-((S)-pyrrolidin-2-yl)propanaMide (hydrochloride) VcMMAE N-Boc-(2R,3R,4S)-dolaproine (9H-fluoren-9-yl)Methyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)aMino)-1-Methoxy-2-Methyl-3-oxopropyl)pyrrolidin-1-yl)-3-Methoxy-5-Methyl-1-oxoheptan-4-yl)(Methyl)aMino)-3-Methyl-1-oxobutan-2-yl)aMino)-3-Met MonoMethyl auristatin E

(3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride VcMMAD McMMAE MC-MMAF McMMAD

MonoMethyl Dolastatin 10

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MonoMethylauristatin F MonoMethyl Auristatin F | MMAF MMAF (MonoMethylauristatin F) (2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid (2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Monomethyl auristatin phenylalanine MONOMETHYLAURISTATIN F; MMAF; MONOMETHYL AURISTATIN PHENYLALANINE; 745017-94-1 L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl- F(MMAF) 745017-94-1 MonoMethylauristatin F Tacrinum MMAF MonoMethylauristatin Methyloratatin F Thiazole,2-bromo-6-methyl- MMAF (Synonyms: Monomethylauristatin F) 745017-97-1 (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-Dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid[Monomethylauristatin F (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-Dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid (2S)-2-[(2R)-2-[(R)-[(2S)-1-[(3R,4S,5S)-4-[(2S)-N,3-dimethyl-2-[(2S)-3-methyl-2-(methylamino)butanamido]butanamido]-3-methoxy-5-methylheptanoyl]-2-hydrogeniopyrrolidin-2-yl](methoxy)methyl]propanamido]-3-phenylpropanoic acid 745017-94-1 75017-94-1 745017-97-1 ADCs