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R-afatinib

CAS No.: 945553-91-3

Chemical Name:: R-afatinib

Synonyms: Afatinib-2;Afatinib Enantiomer;afatinib impurities139;AFATINIB CHIRAL IMPURITY;(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-;(R,E)-N-(4-((3-Chloro-4- fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinozolin- 6-yl)-4-(dimethylamino)but-2-enamide;(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetra- hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino) but-2-enamide;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-;(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide? (Afatinib Impurity）

CBNumber:: CB62676100

Molecular Formula:: C24H25ClFN5O3

Molecular Weight:: 485.94

MOL File:: 945553-91-3.mol

Modify Date:: 2024/6/5 17:10:12

Request For Quotation

R-afatinib Properties

Boiling point	676.9±55.0 °C(Predicted)
Density	1.380±0.06 g/cm3(Predicted)
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	11.79±0.43(Predicted)
color	Pale Beige to Pale Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

R-afatinib Chemical Properties,Uses,Production

Uses

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, is an impurity of Afatinib (A355300) an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

R-afatinib Preparation Products And Raw materials

Raw materials

Preparation Products

R-afatinib Suppliers

Global( 71)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15395	58	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49739	58	Inquiry
China National Standard Pharmaceutical Corporation Limited	+8615391658522	China	11927	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
BOC Sciences	58
career henan chemical co	58
ANHUI WITOP BIOTECH CO., LTD	58
AFINE CHEMICALS LIMITED	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
China National Standard Pharmaceutical Corporation Limited	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
LEAPCHEM CO., LTD.	58

945553-91-3(R-afatinib)Related Search:

Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine Afatinib iMpurity 4-Hydroxy 4-Dedimethylamino Afatinib

Afatinib-d6 TRANS-4-AMINOCROTONIC ACID Afatinib impurity 33 Afatinib impurity 40 Afatinib Impurity 74

Afatinib IMpurity H Afatinib Impurity L (Afatinib N-Oxide) Afatinib Impurity 22 Afatinib impurity 30 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE

Afatinib impurity 27 Afatinib impurity 34 Afatinib impurity 41

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2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)- (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetra- hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino) but-2-enamide (R,E)-N-(4-((3-Chloro-4- fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinozolin- 6-yl)-4-(dimethylamino)but-2-enamide Afatinib impurity 3/R-afatinib/(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Afatinib-2 Afatinib Enantiomer (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)- AFATINIB CHIRAL IMPURITY (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide? (Afatinib Impurity） afatinib impurities139 945553-91-3