OXACILLIN SODIUM
- CAS No.
- 1173-88-2
- Chemical Name:
- OXACILLIN SODIUM
- Synonyms
- p12;OXACILLIN SODIUM SALT;bactocill;prostaphlin;SODIUM OXACILLIN;Oxacillin sodiuM anhydrous;OXACILLIN SODIUM SALT HYDRATE;7-[[3-(2-chlorophenyl)-5-methyl-oxazol-4-yl]carbonylamino]-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid sodium salt monohydrate;oxabel;brl1400
- CBNumber:
- CB6278850
- Molecular Formula:
- C19H18N3NaO5S
- Molecular Weight:
- 423.42
- MOL File:
- 1173-88-2.mol
- Modify Date:
- 2023/7/13 12:29:27
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H334 | |||||||||
| Precautionary statements | P261-P285-P304+P341-P342+P311-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XH9100000 | |||||||||
| Toxicity | cat,LDLo,oral,> 750mg/kg (750mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 322, 1965. | |||||||||
| NFPA 704 |
|
OXACILLIN SODIUM price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 28221 | Oxacillin sodium salt 815-950 μg/mg (Oxacillin) | 1173-88-2 | 1G | ₹4059.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 28221 | Oxacillin sodium salt 815-950 μg/mg (Oxacillin) | 1173-88-2 | 5G | ₹10576.03 | 2022-06-14 | Buy |
OXACILLIN SODIUM Chemical Properties,Uses,Production
Chemical Properties
Crystalline
Uses
Oxacillin sodium salt is a narrow spectrum beta-lactam antibiotic. It can be used in analytical study of combination of reversed phase liquid chromatography and zwitterion exchange-reversed phase-hydrophilic interaction mixed-mode liquid chromatography coupled with mass spectrometry for anal. of antibiotics and their impurities.
Clinical Use
Oxacillin sodium, (5-methyl3-phenyl-4-isoxazolyl)penicillinsodium monohydrate (Prostaphlin), is the salt of a semisyntheticpenicillin that is highly resistant to inactivation bypenicillinase. Apparently, the steric effects of the 3-phenyland 5-methyl groups of the isoxazolyl ring prevent the bindingof this penicillin to the β-lactamase active site and,thereby, protect the lactam ring from degradation in muchthe same way as has been suggested for methicillin. It is alsorelatively resistant to acid hydrolysis and, therefore, may beadministered orally with good effect.
Oxacillin sodium, which is available in capsule form, isreasonably well absorbed from the gastrointestinal (GI)tract, particularly in fasting patients. Effective plasma levelsof oxacillin are obtained in about 1 hour, but despite extensiveplasma protein binding, it is excreted rapidly throughthe kidneys. Oxacillin experiences some first-pass metabolismin the liver to the 5-hydroxymethyl derivative. Thismetabolite has antibacterial activity comparable to that ofoxacillin but is less avidly protein bound and more rapidlyexcreted. The halogenated analogs cloxacillin, dicloxacillin,and floxacillin experience less 5-methyl hydroxylation.
The use of oxacillin and other isoxazolylpenicillinsshould be restricted to the treatment of infections causedby staphylococci resistant to penicillin G. Although theirspectrum of activity is similar to that of penicillin G, theisoxazolylpenicillins are, in general, inferior to it and thephenoxymethylpenicillins for the treatment of infectionscaused by penicillin G-sensitive bacteria. Because isoxazolylpenicillinscause allergic reactions similar to thoseproduced by other penicillins, they should be used withgreat caution in patients who are penicillin sensitive.
Purification Methods
This antibiotic, which is stable to penicillinase, is purified by recrystallisation from isoPrOH and dried in vacuo. Its solubility in H2O at 25o is 5%. [Doyle et al. Nature 192 1183 1961, Review: Chain et al. Antibiotics (Oxford University Press) 2 1949.]
OXACILLIN SODIUM Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| Syschem (India) Limited | +91-7340783755 +91-8968433155 | Haryana, India | 8 | 58 | Inquiry |
| Penam Laboratories Ltd | +91-1145084500 +91-1145084500 | New Delhi, India | 13 | 58 | Inquiry |
| Unimark Remedies Ltd | +91-2267304120 +91-2267304120 | Maharashtra, India | 48 | 58 | Inquiry |
| Dazzle Corporation | 91-22-28878459 | Maharashtra, India | 209 | 58 | Inquiry |
| Syschem (India) Limited. | 91-172-5070471 | Haryana, India | 3 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |