Risdiplam
- CAS No.
- 1825352-65-5
- Chemical Name:
- Risdiplam
- Synonyms
- RG7916;2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one;RO7034067;Risdiplam;2H4]-Risdiplam;Risdiplam (RG7916);Risdiplam (RG-7916, RO-7034067);7-amino-2,3-dihydro-1H-inden-4-ol;RG 7916,Inhibitor,RG-7916,Risdiplam,RO 7034067,DNA/RNA Synthesis,RO-7034067,inhibit;7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one
- CBNumber:
- CB64674494
- Molecular Formula:
- C22H23N7O
- Molecular Weight:
- 401.46
- MOL File:
- 1825352-65-5.mol
- Modify Date:
- 2024/9/3 11:51:57
| Density | 1.50±0.1 g/cm3(Predicted) |
|---|---|
| solubility | Soluble in DMSO |
| pka | 9.41±0.20(Predicted) |
| form | solid |
| color | Light yellow to yellow |
| InChI | InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3 |
| InChIKey | ASKZRYGFUPSJPN-UHFFFAOYSA-N |
| SMILES | C12C=CC(N3CC4(CC4)NCC3)=CN1C(=O)C=C(C1=NN3C=C(C)N=C3C(C)=C1)N=2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Risdiplam Chemical Properties,Uses,Production
Description
Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier.
Chemical Properties
light yellow powder to yellow powder
Uses
Risdiplam is used in preparation of Imidazopyridazinyl Pyridopyrimidinones for treating spinal muscular atrophy. Gene splicing modulator.
Side effects
Body aches or pain, chest pain or tightness, chills, cough, ear congestion, fever, headache, loss of voice, runny or stuffy nose, sneezing, sore throat, trouble breathing, unusual tiredness or weakness and so on.
storage
0-4℃ for short term (days to weeks) or -20℃ for long term (months)
Risdiplam Preparation Products And Raw materials
Raw materials
Preparation Products
Risdiplam Suppliers
Global( 130)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| Jinan Good Medical Technology Co.,Ltd | +86-53155562571 +86-008613553167512 | China | 23 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | China | 1250 | 58 | Inquiry |
| Biopole Pharmatech Co., Ltd. | +8615151475053 | China | 37 | 58 | Inquiry |
| airuikechemical co., ltd. | +undefined86-15315557071 | China | 983 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5873 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| Apeloa production Co.,Limited | +8619933239880 | China | 853 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18648 | 58 | Inquiry |
Related articles
- How is Risdiplam synthesised?
- Risdiplam was approved by the USFDA for the treatment of spinal muscular atrophy caused by a mutation leading to a deficiency ....
- Dec 28，2023
7-amino-2,3-dihydro-1H-inden-4-ol
Risdiplam
RO7034067
4H-Pyrido[1,2-a]pyrimidin-4-one, 7-(4,7-diazaspiro[2.5]oct-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-
Risdiplam (RG-7916, RO-7034067)
RG7916
2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
2H4]-Risdiplam
RG 7916,Inhibitor,RG-7916,Risdiplam,RO 7034067,DNA/RNA Synthesis,RO-7034067,inhibit
2-(4,6-dimethylpyrrolo[1,2-b]pyridazin-2-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one
Risdiplam (RG7916)
1825352-65-5
1825352-65-6