CLONIDINE
- CAS No.
- 4205-90-7
- Chemical Name:
- CLONIDINE
- Synonyms
- Kapvay;734571A;m-5041t;Arkamin;Clonidin;Nexiclon;ST-155-BS;Catapress;CLONIDINE;ClonidinHCl
- CBNumber:
- CB6505769
- Molecular Formula:
- C9H9Cl2N3
- Molecular Weight:
- 230.09
- MOL File:
- 4205-90-7.mol
- Modify Date:
- 2024/8/6 18:38:04
| Melting point | 141-142℃ |
|---|---|
| Boiling point | 369.21°C (rough estimate) |
| Density | 1.3946 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| Flash point | 9℃ |
| storage temp. | -20°C |
| solubility | DMSO:100.0(Max Conc. mg/mL);434.61(Max Conc. mM) |
| pka | 8.10±0.50(Predicted) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 4205-90-7(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- (4205-90-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P330+P331+P310 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
| HS Code | 2933290000 |
| Toxicity | LD50 oral in rat: 67300ug/kg |
CLONIDINE price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C-033 | Clonidine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 4205-90-7 | 1ML | ₹4189.5 | 2022-06-14 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| C-033 | 1ML | ₹4189.5 | Buy |
CLONIDINE Chemical Properties,Uses,Production
Uses
Clonidine may be useful in the treatment of acute opioid withdrawal. Epidural clonidine 1–2μgkg –1 increases the duration and potency of analgesia provided by epidural opioid or local anaesthetic drugs.
Definition
ChEBI: A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Pharmacokinetics
Clonidine is lipid soluble and rapidly absorbed after oral administration, with a peak plasma concentration occurring in 60–90min. O ral, intravenous and intramuscular routes may be used for sedation or analgesia. I n addition, epidural and intrathecal clonidine is used to augment regional anaesthesia, but perineural administration is of limited or no effect. The elimination halflife is 9–13h and is prolonged in renal failure. Fifty percent of an administered dose is excreted unchanged by the kidneys, and 50% is metabolised in the liver to inactive metabolites.
Metabolic pathway
Clonidine is well absorbed orally, with peak plasma concentrations after 60–90min. I t is highly lipid soluble, and approximately 50% is metabolised in the liver to inactive metabolites; the rest is excreted unchanged via the kidneys, with an elimination half-life of 9–12h.
CLONIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Taj Mahal Vision Chemicals Private Limited | 07942557933 | Mumbai, India | 206 | 58 | Inquiry |
| Nephcure Medicines | 08046032407 | Gujarat, India | 3 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | China | 2714 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
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