ISOFENPHOS
- CAS No.
- 25311-71-1
- Chemical Name:
- ISOFENPHOS
- Synonyms
- 40sd;Amaze;pyrfon;Pryfon;discus;le-mat;OFTANOL;B-92114;AMAZE(R);sra12869
- CBNumber:
- CB6667609
- Molecular Formula:
- C15H24NO4PS
- Molecular Weight:
- 345.39
- MOL File:
- 25311-71-1.mol
- Modify Date:
- 2024/12/18 14:08:57
| Melting point | -12℃ |
|---|---|
| Boiling point | bp0.01 120° |
| Density | 1.131 g/cm3 (20 ºC) |
| vapor pressure | 2.2 x 10-4 Pa (20 °C) |
| storage temp. | 0-6°C |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| Water Solubility | 18 mg l-1 (20 °C) |
| pka | -0.30±0.70(Predicted) |
| form | Oil |
| color | Colourless |
| CAS DataBase Reference | 25311-71-1(CAS DataBase Reference) |
| EPA Substance Registry System | Isofenphos (25311-71-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H302+H312+H332-H319-H412 |
| Precautionary statements | P210-P273-P280-P305+P351+P338 |
| Hazard Codes | T,N,Xn,F |
| Risk Statements | 24/25-50/53-52/53-36-20/21/22-11 |
| Safety Statements | 36/37-45-60-61-26-16 |
| RIDADR | 3018 |
| WGK Germany | 2 |
| RTECS | VO4395500 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29299090 |
| Hazardous Substances Data | 25311-71-1(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats, mice (mg/kg): 30-40, 90-130 (Homeyer) |
ISOFENPHOS Chemical Properties,Uses,Production
Chemical Properties
Isofenphos is a colorless oil at room temperature. It is sparingly soluble in water, but soluble in cyclohexone, toluene, acetone, and diethyl ether. The US EPA has grouped isofenphos under RUP, which indicates that qualifi ed, certifi ed, and trained workers are required in the safety management of isofenphos. It is used on turf and ornamental trees and shrubs to control white grubs, mole crickets, and other insects, such as soil-dwelling insects, cabbage root fl ies, corn roundworms, and wire worms.
Uses
Isofenphos is an organophosphorus insecticide used in soil to control leaf-eating and soil-dwelling pests in vegetables, fruits, turf and field crops.
General Description
Colorless oil. Non corrosive. Used as an insecticide.
Air & Water Reactions
Hydrolyzed by alkali solution.
Reactivity Profile
Organothiophosphates, such as ISOFENPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health Hazard
Exposures to isofenphos are highly toxic to animals and humans. Acute and prolonged exposures to high concentrations of isofenphos has caused poisoning with symptoms such as increased secretions, diffi culty in breathing, diarrhea, urination, pupil contraction, slowness of the heart, convulsions, and coma. Isofenphos in combination with malathion cause severe poisoning in humans.
Environmental Fate
Soil. Rapidly degraded by microbes via oxidative desulfuration in soils forming isofenphos
oxon (Abou-Assaf et al., 1986; Abou-Assaf and Coats, 1987; Somasundarum et al.,
1989), isopropyl salicylate and carbon dioxide (Somasundaram et al., 1989). The formation
of isofenphos oxon is largely dependent upon the pH, moisture and temperature of the
soil. The degradation rate of isofenphos decreased with a decrease in temperature (35°C
>25°C >15°C), moisture content (22.5% >30% >15%) and in acidic and alkaline soils
(pH 6 and 8 >pH 7). After isofenphos was applied to soil at a rate of 1,12 kg/ai/ha, concentrations
of 8.3, 7.2, 5.1 and 1.0 ppm were found after 5, 21, 43 and 69 days, respectively.
Following a second application, 4.9, 1.55, 0.25 and 0.10 ppm of isofenphos were found
after 5, 21, 43 and 69 days, respectively (Abou-Assaf and Coats, 1987).
A pure culture of Arthrobacter sp. was capable of degrading isofenphos at different
soil concentrations (10, 50 and 100 ppm) in less than 6 hours. In previously treated soils,isofenphos could be mineralized to carbon dioxide by indigenous microorganisms (
Plant. Two weeks following application to thatch, 65% of the applied amount was
present (Sears et al., 1987).
Surface Water. In estuarine water, the half-life of isofenphos ranged from 9.8 to 11.9
days (Lacorte et al., 1995).
Photolytic. Irradiation of an isofenphos (500 mg) in hexane and methanol (100 mL)
using a high pressure mercury lamp (l = 254–360 nm) for 24 hours yielded the following
products: isofenphos oxon and O-ethyl hydrogen-N-isopropylphosphoroamidothioa
Metabolic pathway
14C-Isofenphos is bioactivated by mixed-function oxidases that ultimately give N-desisopropylisofenphos oxon, a product with 2300-fold greater inhibitory potency than isofenphos oxon towards housefly head acetylcholinesterase.271 By housefly and the cuperous chafer, isofenphos is metabolized to give detoxified metabolites without the bioactivated N- desisopropylisofenphos oxon. No difference in kinds of metabolite is found between the two insects. When rats are administered 14C-isofenphos, most of the radioactivity is recovered from the water fraction of the urine and feces. Aminoisofenphos and isofenphos oxon are detected in the benzene fraction, and the other six metabolites are identified as water-soluble metabolites which include O-ethylhydrogen phosphoramidate and O-ethylhydrogen isopropylphosphoramidothioate. Water-soluble metabolites are predominantly formed through cleavage of the P-O-aryl linkage.
Metabolism
Main degradation route is cleavage of the P?O-aryl ester linkage through oxidative desulfuration to isofenphos oxon followed by hydrolysis and oxidative dearylation from isofenphos. In plant, the major metabolites are salicylic acid and dihydroxybenzoic acid.
ISOFENPHOS Preparation Products And Raw materials
Raw materials
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