Chlorothiazide
- CAS No.
- 58-94-6
- Chemical Name:
- Chlorothiazide
- Synonyms
- Diuril;Flumen;Minzil;Urinex;Alurene;Diupres;Diurite;Diutrid;Salisan;Salunil
- CBNumber:
- CB6756754
- Molecular Formula:
- C7H6ClN3O4S2
- Molecular Weight:
- 295.72
- MOL File:
- 58-94-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:14
| Melting point | 342-343°C |
|---|---|
| Boiling point | 608.8±65.0 °C(Predicted) |
| Density | 1.7303 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Very Slightly, Heated) |
| form | Solid |
| pka | 6.85, 9.45(at 25℃) |
| color | White to Off-White |
| Water Solubility | <0.1 g/100 mL at 19.5 ºC |
| Merck | 14,2168 |
| BCS Class | 4 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | -0.240 |
| CAS DataBase Reference | 58-94-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Chlorothiazide(58-94-6) |
| EPA Substance Registry System | Chlorothiazide (58-94-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H334 |
| Precautionary statements | P261-P272-P280-P284-P302+P352-P304+P340+P312 |
| Hazard Codes | Xn |
| Risk Statements | 42/43-20/21/22 |
| Safety Statements | 36 |
| WGK Germany | 2 |
| RTECS | DK9450000 |
| HS Code | 2935904000 |
Chlorothiazide price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1179 | Chlorothiazide Pharmaceutical Secondary Standard; Certified Reference Material | 58-94-6 | 500MG | ₹8508.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C4911 | Chlorothiazide thiazide diuretic | 58-94-6 | 50G | ₹21985.58 | 2022-06-14 | Buy |
Chlorothiazide Chemical Properties,Uses,Production
Description
Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase in vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.
Chemical Properties
Off-White Solid
Uses
Chlorthiazide is a diuretic that causes the body to excrete excess fluid. This drug exhibits strong diuretic action during both acidosis and alkalosis. It is used for arterial hypertension, in edematous syndromes of various genesis, congestive effects in cardiovascular insufficiency, nephrosis and nephritis, and toxicosis. It is especially recommended for hypertonic illnesses. It lowers intraocular pressure in a number of cases.
Definition
ChEBI: Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent.
General Description
Crystals; white powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Alkaline aqueous solutions will decompose on standing or heating .
Fire Hazard
Flash point data for Chlorothiazide are not available; however, Chlorothiazide is probably combustible.
Mechanism of action
The mechanism of action of Chlorothiazide is an interference with the renal tubular mechanism of electrolyte reabsorption. The diuretic action of chlorothiazide, like other drugs of this series, is caused by reduced absorption of sodium and chloride ions by the kidneys during their simultaneous, intense excretion from the organism.
Safety Profile
Moderately_toxic by intraperitoneal and intravenous routes. Mddly toxic by ingestion. Experimental reproductive effects. Has been implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx NOx and Cl-.
Chlorothiazide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| CTX Lifesciences Pvt Ltd | +91-2612399669 +91-7434851395 | Gujarat, India | 28 | 58 | Inquiry |
| Vasoya Industries Pvt Ltd | +91-9898083583 +91-9898083583 | Gujarat, India | 42 | 58 | Inquiry |
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| Orgamine Chemicals(I) Pvt Ltd | +91-9820080281 +91-9820080281 | Maharashtra, India | 451 | 58 | Inquiry |
| Medinex Laboratories Pvt Ltd | +91-2782883162 +91-2782883161 | Maharashtra, India | 20 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CTX LIFE SCIENCES PVT LTD | +91-261-2398456 | New Delhi, India | 18 | 58 | Inquiry |
| SUN PHARMACEUTICAL INDUSTRIES LTD | (+91 22) 4324 4324 | New Delhi, India | 175 | 58 | Inquiry |
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