3-Amino-1,2,4-Triazole
- CAS No.
- 61-82-5
- Chemical Name:
- 3-Amino-1,2,4-Triazole
- Synonyms
- 3-AMINO-1,2,4-TRIAZOLE;AMITROLE;3-AT;AT;1H-1,2,4-Triazol-3-amine;AMINOTRIAZOLE;3-AMINO-1H-1,2,4-TRIAZOLE;3-Aminotriazole;1H-1,2,3-triazol-4-amine;3-amino-s-triazole
- CBNumber:
- CB6767936
- Molecular Formula:
- C2H4N4
- Molecular Weight:
- 84.08
- MOL File:
- 61-82-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/16 17:35:26
| Melting point | 150-153 °C(lit.) |
|---|---|
| Boiling point | 144.35°C (rough estimate) |
| Density | 1.138 |
| vapor pressure | <0.1 hPa (20 °C) |
| refractive index | 1.6260 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | 280g/l |
| form | Powder or Flakes |
| pka | 11.14±0.20(Predicted) |
| color | White to off-white or yellow |
| PH | 6.4-7.4 (100g/l, H2O, 20℃) |
| Water Solubility | 280 g/L (20 ºC) |
| Merck | 14,489 |
| BRN | 107687 |
| Exposure limits | NIOSH REL: TWA 0.2 mg/m3; ACGIH TLV: TWA 0.2 mg/m3. |
| Stability | Stable. Incompatible with iron, copper, aluminium, acids, alkalies, strong oxidizing agents, acid chlorides, acid anhydrides. Forms chelates with some metals. Moisture sensitive. |
| LogP | -0.860 |
| CAS DataBase Reference | 61-82-5(CAS DataBase Reference) |
| IARC | 3 (Vol. 79, Sup 7) 2001 |
| NIST Chemistry Reference | 3-Amino-s-triazole(61-82-5) |
| EPA Substance Registry System | Amitrole (61-82-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H360D | |||||||||
| Precautionary statements | P202-P264-P280-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn,N,T | |||||||||
| Risk Statements | 48/22-51/53-63-40-61 | |||||||||
| Safety Statements | 13-36/37-61-45-53 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| OEB | C | |||||||||
| OEL | TWA: 0.2 mg/m3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XZ3850000 | |||||||||
| Autoignition Temperature | >225 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339990 | |||||||||
| Toxicity | LD50 in mice, rats (g/kg): 14.7, 25.0 orally (Krller) | |||||||||
| NFPA 704 |
|
3-Amino-1,2,4-Triazole price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A8056 | 3-Amino-1,2,4-triazole ≥95% (TLC) | 61-82-5 | 10G | ₹3615.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SAB1304379 | ANTI-TAS1R2 (C-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 61-82-5 | 400μL | ₹47796.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B4312 | BTK, active, His tagged human PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 61-82-5 | 10μG | ₹48240.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A8056 | 3-Amino-1,2,4-triazole ≥95% (TLC) | 61-82-5 | 25G | ₹6754.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A8056 | 3-Amino-1,2,4-triazole ≥95% (TLC) | 61-82-5 | 100G | ₹16692.15 | 2022-06-14 | Buy |
3-Amino-1,2,4-Triazole Chemical Properties,Uses,Production
Chemical Properties
white powder or crystals
Uses
catalase inhibitor
Definition
A powerful plant growth suppressant and cotton defoliant that is readily absorbed by leaves and roots. 3-Amino-1,2,4-Triazole inhibits many aspects of growth and differentiation including cell division in the primary root meristems in some plants.
Production Methods
3-Amino-1,2,4-Triazole（Amitrole） is synthesized by condensing formic acid with aminoguanidine and can be purified by recrystallization from methanol.
General Description
Odorless white crystals or white powder. Bitter taste. Melting point 147-159°C. Sublimes undecomposed at reduced pressure. Used as a post-emergence herbicide.
Air & Water Reactions
Water soluble. Aqueous solutions are neutral. Dust may form an explosive mixture in air.
Reactivity Profile
3-Amino-1,2,4-Triazole is a triazole derivative. The triazoles are a group that contain several derivatives that are highly explosive materials. They are sensitive to heat, friction, and impact. Sensitivity varies with the type substitution to the triazole ring. Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. It forms chelates with some metals. 3-Amino-1,2,4-Triazole is corrosive to iron, copper and aluminum. Forms salts with most acids and alkalis. It is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides .
Hazard
Toxic; carcinogen.
Health Hazard
Amitrole (3-Amino-1,2,4-Triazole) has low acute toxicity;
in experimental animal studies subchronic
exposures were associated with changes in the
thyroid and chronic exposures were
carcinogenic.
Intentional ingestion of a mixture that contained
20 mg/kg amitrole did not cause any
signs of intoxication.1 In one reported case
study, inhalation of a large amount of amitrolecontaining
herbicide was associated with acute
toxic reaction of the lungs.2 Lung injury was
thought to be secondary to direct toxic damage
to the alveolar lining cells. The remarkable lack
of any other reports describing pulmonary toxicity
of this herbicide was noted, in addition to
the presence of other chemicals in the herbicide
solution.
Fire Hazard
Literature sources indicate that Triazol-3-amine is non-combustible.
Agricultural Uses
Herbicide, Plant growth regulator: A non-food use herbicide for control of grasses, woody plants and broad-leaf weeds on hard surface and in areas where crops are not normally grown.
Trade name
AMITRIL®; ATLAZIN®; ATLAZINE® FLOWABLE; AT®; 3-AT®; AT-90®; ATRAFLOW PLUS®; AZAPLANT®; AZAPLANT KOMBI®; AZOLAN®; AZOLE®; BOROFLOW® A/ATA; CAMPAPRIM® A 1544; CDA SIMFLOW PLUS®; CHIPMAN® PATH; CYTROLE®; DIUROL® AMITROLE; DOMATOL®; ELMASIL®; EMISOL®; FARMCO®; HERBAZIN PLUS SC®; HERBICIDE® TOTAL; MASCOT HIGHWAY®; MSS AMINOTRIAZOLE®; MSS SIMAZINE®; ORGA-414®; RADOXONE® TL; RAMIZOL®; RASSAPRON®; SIMAZOL®; SIMFLOW PLUS®; SOLUTION CNCENTREE T271®; SYNCHEMICALS® TOTAL WEED KILLER; SYNTOX®; TORAPRON®; VOROX®; WEEDAR®; WEEDAZIN®; WEEDAZOL TL ®; WEEDOCLOR®
Safety Profile
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,. An herbicide and plant growth regulator
Potential Exposure
A potential danger to those involved in the manufacture, formulation, and application of this postemergence herbicide, which is now limited to noncrop applications as a herbicide and plant growth regulator. Some triazoles have been used as rubber components.
Carcinogenicity
Amitrole is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
Soil. When radiolabeled amitrole-5-14C was incubated in a Hagerstown silty clay loam,
50 and 70% of the applied amount evolved as 14CO2 after 3 and 20 days, respectively. In
autoclaved soil, however, no 14CO2 was detected. The chemical degradation in soil was
probably via hydroxyl radicals (Kaufman et al., 1968). The average persistence in soils is
2–4 weeks (Hartley and Kidd, 1987)
Plant.Amitrole is transformed in plants to form the conjugate β-(3-amino-1,2,4-triazol-
1-yl)-α-alanine (Humburg et al., 1989) and/or 3-(3-amino-s-triazole-1-yl)-2-aminopropionic acid (Duke et al., 1991). Amitrole is metabolized in Canada thistl
Surface Water. In pond water, adsorption to suspended sediments was an important
process. The initial half-life was reported to be no more than 68 days. After 120 days,
20% of the applied amount remained (Grzenda et al., 1966). The biodegradation
Photolytic. Direct photolysis of amitrole is not expected to occur since the herbicide
shows little or no absorption greater than 295 nm (Gore et al., 1971)
Chemical/Physical. Reacts with acids and bases forming soluble salts (Hartley and
Kidd, 1987). Emits toxic fumes of nitrogen oxides when heated to decomposition (Sax
and Lewis, 1987); however, incineration with polyethylene results in more than 9
Shipping
UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
Purification Methods
It crystallises from EtOH (charcoal), then three times from dioxane [Williams et al. J Phys Chem 61 261 1957]. [Beilstein 26 H 137.] Possible carcinogen. [Beilstein 26 H 137, Temple & Montgomery 1,2,4-Triazoles —The Chemistry of Heterocyclic Compounds Vol 37 (Weissberger & Taylor eds.). Wiley & Sons NY 1981, ISBN 0-471-0656-6.]
Incompatibilities
Dust may be explosive in air. Keep away from strong oxidizers; strong acids; light and heat (decomposes). Corrosive to iron, aluminum, and copper. Sublimes undecomposed at reduced pressure.
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Amitrol is resistant to hydrolysis and the action of oxidizing agents. Burning the compound with polyethylene is reported to result in .99% decomposition.
3-Amino-1,2,4-Triazole Preparation Products And Raw materials
Raw materials
Preparation Products
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