2-Bromo-3',4'-(methylenedioxy)propiophenone
![2-Bromo-3',4'-(methylenedioxy)propiophenone Structure](CAS/GIF/52190-28-0.gif)
- CAS No.
- 52190-28-0
- Chemical Name:
- 2-Bromo-3',4'-(methylenedioxy)propiophenone
- Synonyms
- Bromo-3′ , 4′ - (methylenedioxy);3',4'-Methylenedioxy-α-broMopropiophenone;3',4'-Methylenedioxy-α-broMopropiophenone;2-Bromo-3',4'-(methylenedioxy)propiophenone;2-Bromo-3',4'-(methylenedioxy)propiophenone;1-(1,3-benzodioxol-5-yl)-2-bromopropan-1-one;1-(1,3-Benzodioxol-5-yl)-2-broMo-1-propanone;1-Propanone, 1-(1,3-benzodioxol-5-yl)-2-bromo-;1-(benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one;Name 2-Bromo-3',4'-(methylenedioxy)propiophenone
- CBNumber:
- CB6966513
- Molecular Formula:
- C10H9BrO3
- Molecular Weight:
- 257.08
- MOL File:
- 52190-28-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/5 12:01:54
Boiling point | 345.7±42.0 °C(Predicted) |
---|---|
Density | 1.584±0.06 g/cm3(Predicted) |
solubility | Chloroform: Soluble; DMSO: 1 mg/mL*; Ethanol: 1 mg/mL |
form | A crystalline solid |
InChI | InChI=1S/C10H9BrO3/c1-6(11)10(12)7-2-3-8-9(4-7)14-5-13-8/h2-4,6H,5H2,1H3 |
InChIKey | NTPQGLLTGPTOAA-UHFFFAOYSA-N |
SMILES | C(C1=CC=C2OCOC2=C1)(=O)C(Br)C |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS05 |
---|---|
Signal word | Danger |
Hazard statements | H314 |
Precautionary statements | P264-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P363-P405-P501 |
2-Bromo-3',4'-(methylenedioxy)propiophenone Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
1-(benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one (2-Bromo-3',4'-(methylenedioxy)propiophenone) can be used in the preparation of antifungal agents and MDMA analogs.
Application
2-Bromo-3',4'-(methylenedioxy)propiophenone, also known as 4′-(methylenedioxy)propiophenone, is an analytical reference standard categorized as a precursor in the synthesis of cathinones. This product is intended for research and forensic applications.
Synthesis
Bromine (10.0 mmol) was added to a solution of the ketone (10.0 mmol) in Et2O (25 mL). The solution was stirred for 30 min (until the color of the solution changed from red to light-yellow). Then, the reaction was quenched with water (10 mL), and the mixture was diluted with Et2O (25 mL). The organic layer was washed with a saturated solution of aqueous NaHCO3 (30 mL), a saturated solution of aqueous Na2S2O3 (30 mL), and brine (30 mL), and then it was dried over MgSO4, filtered, and concentrated. The α-bromoketone was purified by flash chromatography on silica gel. 2-Bromo-3',4'-(methylenedioxy)propiophenone [52190-28-0]. This compound was prepared according to the General Procedure from 3,4-methylenedioxypropiophenone (1.78 g, 10.0 mmol). The product was obtained as a white solid (eluted with 50% CH2Cl2 in hexanes; 2.13 g, 82% yield). 1H NMR (CDCl3, 500 MHz) δ 7.64 (d, J= 8.0 Hz, 1H), 7.49 (s, 1H), 6.87 (d, J= 8.0 Hz, 1H), 6.07 (s, 2H), 5.21 (q, J= 7.0 Hz, 1H), 1.88 (d, J= 7.0 Hz, 3H).
2-Bromo-3',4'-(methylenedioxy)propiophenone Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | China | 3144 | 58 | Inquiry |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | China | 3581 | 58 | Inquiry |
Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | China | 305 | 58 | Inquiry |
Wuhan Ruichi Technology Co., Ltd | +8613545065237 | China | 161 | 58 | Inquiry |
Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 | China | 999 | 58 | Inquiry |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | China | 3878 | 58 | Inquiry |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | China | 436 | 58 | Inquiry |
Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 | China | 145 | 58 | Inquiry |
Shaanxi Franta Biotechnology Co., Ltd | +86-13082019107 +86-13082019107 | China | 225 | 58 | Inquiry |
Apeloa production Co.,Limited | +8619933239880 | China | 853 | 58 | Inquiry |