Clidanac
- CAS No.
- 34148-01-1
- Chemical Name:
- Clidanac
- Synonyms
- Britai;Indanal;Clidanaco;Clidanac USP/EP/BP;6-Chloro-5-cyclohexyl-1-indancarboxylic acid;6-Chloro-5-cyclohexyl-1-indanecarboxylic acid;6-chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid;1H-Indene-1-carboxylic acid, 6-chloro-5-cyclohexyl-2,3-dihydro-;1H-Indene-1-carboxylic acid, 6-chloro-5-cyclohexyl-2,3-dihydro- (9ci)
- CBNumber:
- CB71134525
- Molecular Formula:
- C16H19ClO2
- Molecular Weight:
- 278.77
- MOL File:
- 34148-01-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/21 14:17:16
Clidanac Chemical Properties,Uses,Production
Uses
Clidanac can be used as a replacement for retinol for skin treatment, to treat anal fissures, and as a preparation of ester prodrugs of NSAIDs.
Trade name
Britai (Bristol Banyu, Japan), Indanal (Takeda, Japan).
Clinical Use
Clidenac is used for the relief of pain and in- flammation related to arthrosis deformans, periarthritis humeroscapularis, cervical syndrome, and lumbago.
Synthesis
Synthesis: formylation of cyclohexylbenzene using dichloromethyl methyl
ether and titanium tetrachloride gives 4-
cyclohexylbenzaldehyde, which is condensed
with diethyl malonate to yield diethyl 4-
cyclohexylbenzylidenemalonate. Treatment
of the latter with potassium cyanide in
ethanol at 70 ?C gives ethyl 3-cyano-3-(4-
cyclohexylphenyl)propionate, which is converted to 4-cyclohexylphenylsuccinic anhydride following acid hydrolysis and treatment with refluxing acetic anhydride. An intramolecular Friedel – Crafts acylation (aluminum chloride – methylene chloride) affords
5-cyclohexyl-3-oxo-1-indanecarboxylic acid,
which is catalytically reduced using 10 % palladium on charcoal in the presence of perchloric
acid to give 5-cyclohexyl-1-indanecarboxylic
acid. Chlorination using N-chlorosuccinimide
in N,N-dimethylformamide (DMF) gives clidenac.
Clidanac Preparation Products And Raw materials
Clidanac Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24330 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 23963 | 58 | Inquiry |
| Shanghai New Union Textra Import & Export Co., Ltd | +861-348-227-9455 | China | 2752 | 60 | Inquiry |
| Waterstone Technology, LLC | 317 644 0862 | United States | 6801 | 30 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |