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MENTHOL

MENTHOL Structure
CAS No.
15356-70-4
Chemical Name:
MENTHOL
Synonyms
D-Menthol;Menthol racemic;2-Isopropyl-5-methylcyclohexanol;racementhol;FEMA 2665;MENTHOL;NCI-C50000;3-p-Menthol;d,1-menthol;MENTHOL, DL-
CBNumber:
CB7116412
Molecular Formula:
C10H20O
Molecular Weight:
156.27
MOL File:
15356-70-4.mol
MSDS File:
SDS
Modify Date:
2024/3/11 22:19:25

MENTHOL Properties

Melting point 34-36 °C(lit.)
Boiling point 216 °C(lit.)
Density 0.89 g/mL at 25 °C(lit.)
vapor pressure 0.8 mm Hg ( 20 °C)
FEMA 2665 | MENTHOL RACEMIC
refractive index 1.4615
Flash point 200 °F
storage temp. 2-8°C
solubility Practically insoluble in water, very soluble in ethanol (96 per cent) and in light petroleum, freely soluble in fatty oils and in liquid paraffin, very slightly soluble in glycerol.
form cryst.
color White
Dielectric constant 3.2(Ambient)
InChIKey NOOLISFMXDJSKH-UHFFFAOYSA-N
CAS DataBase Reference 15356-70-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H302-H315-H319-H331-H336-H351-H361d-H372
Precautionary statements  P202-P301+P312-P302+P352-P304+P340+P311-P305+P351+P338-P308+P313
Hazard Codes  Xn,Xi
Risk Statements  37/38-41-48/20/22-40-38-22
Safety Statements  36/37/39-36-26
RIDADR  UN 1888 6.1/PG 3
WGK Germany  2
RTECS  OT0525000
HS Code  29061100

MENTHOL price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) CRM40467 D,L-Menthol solution certified reference material, 2000?μg/mL in methanol, ampule of 1?mL 15356-70-4 1ML ₹11225.2 2022-06-14 Buy
Product number Packaging Price Buy
CRM40467 1ML ₹11225.2 Buy

MENTHOL Chemical Properties,Uses,Production

Chemical Properties

Racemic menthol is a mixture of equal parts of the (1R,2S,5R)- and (1S,2R,5S)-isomers of menthol. It is a free-flowing or agglomerated crystalline powder, or colorless, prismatic, or acicular shiny crystals, or hexagonal or fused masses with a strong characteristic odor and taste. The crystalline form may change with time owing to sublimation within a closed vessel. The USP 32 specifies that menthol may be either naturally occurring l-menthol or syntheti-cally prepared racemic or dl-menthol. However, the JP XV and PhEur 6.0, along with other pharmacopeias, include two separate monographs for racemic and l-menthol.

Physical properties

Physical Properties. The eight optically active menthols differ in their sensory properties. (?)-Menthol has a characteristic peppermint odor and also exerts a cooling effect. The other isomers do not possess this cooling effect and are, therefore, not considered to be “refreshing.” Racemic menthol occupies an intermediate position; the cooling effect of the (?)-menthol present is distinctly perceptible.
The enantiomeric menthols have identical physical properties (apart from their specific rotations), but the racemates differ from the optically active forms in, for example, theirmelting points.Although the differences between the boiling points are small, the (racemic) stereoisomers can be separated by fractional distillation. Boiling points (in °C at 101.3 kPa) are as follows:
rac-neomenthol, 211.7
rac-neoisomenthol 214.6
rac-menthol, 216.5
rac-isomenthol, 218.6
Other physical constants of commercially available levorotatory and racemic menthols are as follows: (?)-menthol, mp 43 °C, [α]20 D ?50° (ethanol, 10%); racemic menthol, mp 38 °C.
Chemical Properties. Hydrogenation of menthols yields p-menthane; oxidation with chromic acid or catalytic dehydrogenation yields menthones. Dehydration under mild conditions yields 3-p-menthene as the main product. Reaction with carboxylic acids or their derivatives yields menthyl esters, which are used mainly as aroma substances and in pharmaceutical preparations and formulations. The esterification of menthols with benzoic acid is used on an industrial scale in the resolution of racemic menthol.

Occurrence

Has apparently not been reported to occur in nature

Indications

Menthol, a cyclic alcohol (derived from peppermint, other mint oils, or prepared synthetically), relieves itching by generating a cool sensation. It is usually used in 0.25% to 2% concentrations but is present in concentrations as high as 16% in some OTC products.

Preparation

By hydrogenation of thymol followed by separation from its other isomers.

Production Methods

Menthol occurs widely in nature as l-menthol and is the principal component of peppermint and cornmint oils obtained from the Mentha piperita and Mentha arvensis species. Commercially, lmenthol is mainly produced by extraction from these volatile oils. It may also be prepared by partial or total synthetic methods.
Racemic menthol is prepared synthetically via a number of routes, e.g. by hydrogenation of thymol.

Pharmaceutical Applications

Menthol is widely used in pharmaceuticals, confectionery, and toiletry products as a flavoring agent or odor enhancer. In addition to its characteristic peppermint flavor, l-menthol, which occurs naturally, also exerts a cooling or refreshing sensation that is exploited in many topical preparations. Unlike mannitol, which exerts a similar effect due to a negative heat of solution, l-menthol interacts directly with the body’s coldness receptors. d-Menthol has no cooling effect, while racemic menthol exerts an effect approximately half that of l-menthol.
When used to flavor tablets, menthol is generally dissolved in ethanol (95%) and sprayed onto tablet granules and not used as a solid excipient.
Menthol has been investigated as a skin-penetration enhancer and is also used in perfumery, tobacco products, chewing gum and as a therapeutic agent. When applied to the skin, menthol dilates the blood vessels, causing a sensation of coldness followed by an analgesic effect. It relieves itching and is used in creams, lotions, and ointments. When administered orally in small doses menthol has a carminative action.

Safety Profile

Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An eye and skin irritant. K%en heated to decomposition it emits acrid smoke and irritating fumes. See also MENTHOL and 1-MENTHOL.

Safety

Almost all toxicological data for menthol relate to its use as a therapeutic agent rather than as an excipient. Inhalation or ingestion of large quantities can result in serious adverse reactions such as ataxia and CNS depression,hypersensitivity reactions, severe abdominal pain, nausea, vomiting, vertigo, drowsiness, and coma.Although menthol is essentially nonirritant there have been some reports of hypersensitivity following topical application. In a Polish study approximately 1% of individuals were determined as being sensitive to menthol.There have been reports of apnea and instant collapse in infants after the local application of menthol to their nostrils.
The WHO has set an acceptable daily intake of menthol at up to 0.4 mg/kg body-weight.
LD50 (rat, IM): 10.0 g/kg
LD50 (rat, oral): 3.18 g/kg

Metabolism

Rabbits are said to eliminate 59% of dl-menthol as glucuronide (Williams, 1938).

storage

A formulation containing menthol 1% w/w in aqueous cream has been reported to be stable for up to 18 months when stored at room temperature.
Menthol should be stored in a well-closed container at a temperature not exceeding 25°C, since it sublimes readily.

Incompatibilities

Incompatible with: butylchloral hydrate; camphor; chloral hydrate; chromium trioxide; b-naphthol; phenol; potassium permanganate; pyrogallol; resorcinol; and thymol.

Regulatory Status

Included in the FDA Inactive Ingredients Database (dental preparations, inhalations, oral aerosols, capsules, solutions, suspensions, syrups, and tablets; also topical preparations). Included in nonparenteral medicines licensed in the UK. Accepted for use in foods and confectionery as a flavoring agent of natural origin. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

MENTHOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-p-Menthol 4-Isopropyl-1-methylcyclohexan-3-ol mentholracemique NCI-C50000 MENTHOL, DL- (+/-)-MENTHOL MENTHOL HEXAHYDROTHYMOL 2-ISOPROPYL-5-METHYLCYCLOHEXANOL DL-MENTHAN-3-OL DL-4-MENTHAN-3-OL DL-2-ISOPROPYL-5-METHYLCYCLOHEXANOL 5-METHYL-2-(1-METHYETHYL)CYCLOHEXANOL (1RS,3RS,4SR)-4 MENTHAN-3-OL DL-Menthol, racemic CYCLOHEXANOL,5-METHYL-2-(1-ME Menthol solution DL-MENTHOL USP (RACEMIC) SYNTHETIC D,L-Menthol solution mentholracemic Menthol, cis-1,3,trans-1,4-(.+/-.)- Menthol, cis-1,3,trans-1,4-(± Menthol, (± Menthol racemique dl-3-p-Menthanol d,1-menthol cyclohexanol,5-methyl-2-(1-methylethyl)-,(1-alpha,2-beta,5-alpha) Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1alpha,2beta,5alpha)-(± cis-1,3-trans-1,4-(+-)-mentho 5-methyl-2-(1-methylethyl)-,(1alpha,2beta,5alpha)-(+/-)-cyclohexano 5-methyl-2-(1-methylethyl)-,(1.alpha.,2.beta.,5.alpha.)-(+-)-Cyclohexanol (+/-)-p-Menthan-3-ol Menthol cristal racementhol FEMA 2665 2-Isopropyl-5-methylcyclohexanol D-Menthol Menthol racemic 15356-70-4 Building Blocks Terpenes Monocyclic Monoterpenes Organic Building Blocks Oxygen Compounds C9 to C30 Alcohols MEA - MESAnalytical Standards Alphabetic M NMR Reference Standards NMRStable Isotopes Spectroscopy Biochemistry Monocyclic Monoterpenes Terpenes