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Hydrocortisone acetate

CAS No.: 50-03-3

Chemical Name:: Hydrocortisone acetate

Synonyms: HYDROCORTISONE 21-ACETATE;CORTISOL ACETATE;CORTISOL 21-ACETATE;Cortef;Epifoam;Cortifoam;Fernisone;Carmol HC;Hc45;Mysone

CBNumber:: CB7196805

Molecular Formula:: C23H32O6

Molecular Weight:: 404.5

MOL File:: 50-03-3.mol

Modify Date:: 2024/9/24 13:09:20

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Hydrocortisone acetate Properties

Melting point	223 °C (dec.)(lit.)
Boiling point	446.1°C (rough estimate)
alpha	D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone)
Density	d420 1.289
refractive index	1.4593 (estimate)
Flash point	223°C
storage temp.	0-6°C
solubility	Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride
pka	12.42±0.70(Predicted)
form	Solid
color	White to Off-White
Water Solubility	Insoluble in water.
Decomposition	223 ºC
Merck	14,4787
BRN	2066841
Stability	Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.
LogP	2.190
CAS DataBase Reference	50-03-3(CAS DataBase Reference)
NIST Chemistry Reference	Hydrocortisone acetate(50-03-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Danger

Hazard statements

H360Df-H373

Precautionary statements

P202-P260-P280-P308+P313-P405-P501

Hazard Codes

Xn,T

Risk Statements

63-10-45

Safety Statements

36/37-45-53

WGK Germany

RTECS

GM8960000

HS Code

29372100

Toxicity

LD50 intraperitoneal in mouse: 2300mg/kg

NFPA 704

	1
0		0

Hydrocortisone acetate price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	H4126	Hydrocortisone 21-acetate ≥98% (HPLC)	50-03-3	1G	₹2987.7	2022-06-14	Buy
Sigma-Aldrich(India)	H4126	Hydrocortisone 21-acetate ≥98% (HPLC)	50-03-3	5G	₹10197.15	2022-06-14	Buy
Sigma-Aldrich(India)	H4126	Hydrocortisone 21-acetate ≥98% (HPLC)	50-03-3	10G	₹18835.5	2022-06-14	Buy
TCI Chemicals (India)	H0184	Hydrocortisone Acetate	50-03-3	1G	₹3600	2022-05-26	Buy
TCI Chemicals (India)	H0184	Hydrocortisone Acetate	50-03-3	5G	₹6900	2022-05-26	Buy

Product number	Packaging	Price	Buy
H4126	1G	₹2987.7	Buy
H4126	5G	₹10197.15	Buy
H4126	10G	₹18835.5	Buy
H0184	1G	₹3600	Buy
H0184	5G	₹6900	Buy

Hydrocortisone acetate Chemical Properties,Uses,Production

Chemical Properties

white powder

Uses

Hydrocortisone acetate is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is used to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions).

Purification Methods

The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.]

Hydrocortisone acetate Preparation Products And Raw materials

Raw materials

Pyridine Saponin Hydrocortisone

Preparation Products

Pregn-4-ene-3,20-dione, 2,11,17,21-tetrahydroxy-, (2α,11β)- (9CI) 6-Dehydrocortisol Acetate

Hydrocortisone acetate Suppliers

Global( 608)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
AnalyticsStanza Inc	+91-7032031309 +91-7032031309	Hyderabad, India	227	58	Inquiry
GLP Pharma Standards	+91 9866074638	Hyderabad, India	1644	58	Inquiry
Anuh Pharma Ltd (SK GROUP)	+912266227575	Maharashtra, India	38	58	Inquiry
Horster Biotek Pvt Ltd	+91-7359657360 +91-9898127219	Gujarat, India	58	58	Inquiry
Stermone Chemicals Pvt Ltd	+91-9328939700 +91-9328939700	Gujarat, India	20	58	Inquiry
Maharshi Pharma Chem	+91-7940359347 +91-7433927173	Gujarat, India	24	58	Inquiry
Prachem Laboratories	+91-7948993109 +91-7383072020	Gujarat, India	44	58	Inquiry
Envee Drugs Pvt Ltd	+91-02682559595 +91-8866665858	Gujarat, India	36	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Gonane Pharma	+91-9819380043 +91-9819380043	NaviMumbai, India	192	58	Inquiry

Supplier	Advantage
AnalyticsStanza Inc	58
GLP Pharma Standards	58
Anuh Pharma Ltd (SK GROUP)	58
Horster Biotek Pvt Ltd	58
Stermone Chemicals Pvt Ltd	58
Maharshi Pharma Chem	58
Prachem Laboratories	58
Envee Drugs Pvt Ltd	58
Ralington Pharma	58
Gonane Pharma	58

Hydrocortisone Acetate: Chemical Properties, Applications, and Storage in Modern Pharmaceuticals
Hydrocortisone acetate, a synthetic derivative of the natural steroid hormone hydrocortisone, is widely used in the pharmaceut....
Sep 24，2024

Hydrocortisone acetate Spectrum

Hydrocortisone acetate(50-03-3)MS Hydrocortisone acetate(50-03-3)IR1 Hydrocortisone acetate(50-03-3)IR2

50-03-3(Hydrocortisone acetate)Related Search:

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ACETATE 4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-CAPRYLATE HYDROCORTISONE CYPIONATE (200 MG)

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(11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione 11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate 11-beta,17-alpha-dihydroxy-21-acetoxypregesterone 11beta17alpha-Dihydroxy-21-acetoxypregesterone 17-alpha-hydrocorticosterone21-acetate 17alpha-Hydrocorticosterone-21-acetate 17-dihydroxy-20-dion(11-beta)-pregn-4-ene-21-(acetoxy)-11 17-dihydroxy-20-dion(11beta)-pregn-4-ene-21-(acetyloxy)-11 17-hydroxy-corticosteron21-acetate 20-dione,11-beta,17,21-trihydroxy-pregn-4-ene-21-acetate 21-acetoxy-11-beta,17-alpha-dihydroxypregn-4-ene-3,20-dione 21-Acetoxy-11beta17alpha-dihydroxypregn-4-ene-3,20-dione Abbocort Acetate-as Aceto-Cort Anusol-HC Bambicort Berlison F berlisonf Corticosterone, 17-hydroxy-, 21-acetate Cortril acetate Cortril acetate-AS cortrilacetate cortrilacetate-as Efcolin Eye-Cort Hc45 Hycortole acetate hycortoleacetate Hydrocal Hydrocortisat Hydrocortistab Hydrosone Hydroxycorticosterone acetate hydroxycorticosteroneacetate Hysone-A Isopto-Hydrocortisone Lenirit Mysone NSC 741 4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE 4-PREGNEN-11BETA,17ALPHA,21-TETROL-3,20-DIONE 21-ACETATE 4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE Hydrocortisone Acetate BP/USP/EP HYDROCORTISONE ACETATE, PH EUR HYDROCORTISONE ACETATE USP HYDROCORTISON 21-ACETATE VETRANAL, 250 M 11β,17α,21-trihydroxy-4-pregnene-3,20-dione 21-acetate HYDROCORTISONEACETATE,MICRONIZED,USP 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate 21-Acetoxy-11β,17-dihydroxypregn-4-en-3,20-dione 21-Acetoxy-11β,17-dihydroxypregn-4-ene-3,20-dione 21-Acetoxy-11β,17α-dihydroxypregn-4-ene-3,20-dione Cortisol acetate (6CI) Cortisol, 21-acetate (7CI, 8CI) Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11β)- Hydrocortisone acetate usp 36 Hydrocortisone-AcetatePuriss