5-propylbenzene-1,3-diol
- CAS No.
- 500-49-2
- Chemical Name:
- 5-propylbenzene-1,3-diol
- Synonyms
- Divarinol;Divarin;5-Propyl-1,3-benzenedio;5-propylbenzene-1,3-diol;5-Propyl-1,3-benzenediol;3,5-Dihydroxypropylbenzene;1,3-Benzenediol, 5-propyl-;3,5-Dihydroxy-1-propylbenzene;1,3-Benzenediol, 5-propyl- CAS NO.500-49-2
- CBNumber:
- CB72178085
- Molecular Formula:
- C9H12O2
- Molecular Weight:
- 152.19
- MOL File:
- 500-49-2.mol
- Modify Date:
- 2024/6/26 17:50:42
| Melting point | 82.8°C |
|---|---|
| Boiling point | 234.66°C (rough estimate) |
| Density | 1.0505 (rough estimate) |
| refractive index | 1.4024 (estimate) |
| solubility | DMF: 2 mg/ml; DMSO: 2 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 1 mg/ml |
| form | A crystalline solid |
| pka | 9.56±0.10(Predicted) |
| InChI | InChI=1S/C9H12O2/c1-2-3-7-4-8(10)6-9(11)5-7/h4-6,10-11H,2-3H2,1H3 |
| InChIKey | FRNQLQRBNSSJBK-UHFFFAOYSA-N |
| SMILES | C1(O)=CC(CCC)=CC(O)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P271-P261-P280 | |||||||||
| HS Code | 2907290090 | |||||||||
| NFPA 704 |
|
5-propylbenzene-1,3-diol Chemical Properties,Uses,Production
Chemical Properties
A White to Brown crystalline solid.
Description
5-propylbenzene-1,3-diol (5-PBD) is a naturally occurring compound found in several plant species, including the common garden plant, the rose. 5-PBD has been found to possess antifungal, antiviral, anticonvulsant, and anti-inflammatory properties, and has been shown to inhibit the growth of several species of fungi, including Candida albicans and Trichophyton mentagrophytes. Additionally, it has been reported to inhibit the oxidation of lipids in cell cultures.
Uses
5-Propylbenzene-1,3-diol is an intermediate used to prepare Cannabigerovarin (C175140) which stimulates thermosensitive transient receptor potential (TRP) channels of vanilloid type-4 (TRPV4)-mediated [Ca2+]i with moderate-high efficacy (30-60% of the effect of ionomycin) and potency (EC50 0.9-6.4 μM),
Mechanism of action
5-Propyl-1,3-benzenediol acts by inhibiting the activity of certain enzymes involved in the synthesis of fungal cell wall components, such as β-glucan and chitin, and other enzymes involved in the synthesis of viral proteins, such as reverse transcriptase and protease.
Synthesis
In a 100 mL round bottom flask, open to the atmosphere was added the crude product Benzene, 1,3-dimethoxy-5-propyl (0.736 g, 4.08 mmol, 1.0 equiv.) and a 1:1 mixture of glacial acetic acid (20 mL, 349.7 mmol, 17.4 M) and hydrobromic acid (48% in H2O, 20 mL, 368.3 mmol, 18.4 M). The reaction mixture was refluxed at 125 °C for 3 hours while stirring, or until the starting material was consumed via TLC analysis. At this point, the reaction was allowed to cool to room temperature and quenched by the addition of DI H2O. The biphasic solution was added to a separatory funnel, wherein the organic portion was extracted Et2O (ca. 3x 20 mL). The organic layers were then combined, neutralized with a concentrated sodium bicarbonate solution (ca. 30 mL), washed with a saturated brine solution (ca. 50 mL), dried over MgSO4, filtered, and concentrated in vacuo to afford the final product without 5-Propyl-1,3-benzenediol (5-propylbenzene-1,3-diol) (0.609 g, 99% yield) as a pale yellow oil.
5-propylbenzene-1,3-diol Preparation Products And Raw materials
Raw materials
1of3
chevron_rightPreparation Products
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