AR-A014418
- CAS No.
- Chemical Name:
- AR-A014418
- Synonyms
- AR-A014418;GSK-3BETA INHIBITOR VIII;N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA
- CBNumber:
- CB7226373
- Molecular Formula:
- C12H12N4O4S
- Molecular Weight:
- 308.31
- MOL File:
- Mol file
AR-A014418 Chemical Properties,Uses,Production
Enzyme inhibitor
This ATP-competitive protein kinase inhibitor (FW = 308.31 g/mol; CAS 487021-52-3; Solubility: 62 mg/mL DMSO; <1 mg/mL H2O) selectively targets glycogen synthase kinase 3β (GSK3β),with IC50 = 104 nM; Ki = 38 nM. Attesting to its high specificity for GSK3, AR-A014418 does not significantly inhibit Cdk2 or Cdk5 (IC50 > 100 μM) or 26 other kinases. AR-A014418 inhibits phosphorylation of the microtubule-associated protein Tau at Ser-396 (i.e., the GSK3-specific site) in cells stably expressing human four-repeat Tau. AR-A014418 protects N2A neuroblastoma cells against cell death mediated by inhibition of the phosphatidylinositol 3-kinase/protein kinase B survival pathway. AR- A014418 inhibits neurodegeneration mediated by b-amyloid peptide in hippocampal slices. Treatment of neuroblastoma cell lines with AR- A014418 reduced the level of GSK-3α phosphorylation at Tyr-279 compared to GSK-3β phosphorylation at Tyr-216, and attenuated growth via the maintenance of apoptosis.. AR-A014418-dependent antinociceptive effects are induced by modulation of the glutamatergic system through metabotropic and ionotropic (NMDA) receptors and the inhibition of TNF-α and IL-1β cytokine signaling.
AR-A014418 Preparation Products And Raw materials
Raw materials
Preparation Products
AR-A014418 Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
EMD Biosciences, Inc. | 858 450 5500 | United States | 6529 | 66 | Inquiry |
SIGMA-RBI | 800 736 3690 (Orders) | Switzerland | 6913 | 91 | Inquiry |
Wuhan Kehaojia Biotechnology Co., Ltd. | 027-88185565 13164666941 | CHINA | 2650 | 58 | Inquiry |
Nanjing Laifusai Biological Technology Co., Ltd. | 400-9961-933 | CHINA | 6638 | 58 | Inquiry |
Shanghai Yijie Biological Technology Co., Ltd. | 021-24209075 | CHINA | 3510 | 58 | Inquiry |
Boppard-China | 021-62884751 | China | 687 | 58 | Inquiry |
Shanghai Han-Xiang Chemical Co., Ltd. | +86 (21) 5027-2946, +86 13818785766 | China | 1039 | 50 | Inquiry |
Shanghai Yaoyun Biological Technology Co., Ltd. | 400-002-6926 400-002-6926 | CHINA | 6852 | 58 | Inquiry |
Absin Bioscience Inc. | 021-38015121 | CHINA | 6661 | 58 | Inquiry |
Shanghai Ziqi Biological Technology Co., Ltd. | 400-811-9081 13681619662 | CHINA | 6192 | 58 | Inquiry |