ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >mTOR inhibitors >42-(Dimethylphosphinate)rapamycin
42-(Dimethylphosphinate)rapamycin
- CAS No.
- 572924-54-0
- Chemical Name:
- 42-(Dimethylphosphinate)rapamycin
- Synonyms
- Ridaforolimus;Deforolimus;DeforoliMus API;Ridaforolimus, >RidaforoliMus, >80%;DeforoliMus(MK-8669);Deforolimus (AP23573);deforolimus 572924-54-0;Ridaforolimus (MK-8669);Deforolimus (AP23573)42-
- CBNumber:
- CB72462148
- Molecular Formula:
- C53H84NO14P
- Molecular Weight:
- 990.21
- MOL File:
- 572924-54-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:20
| Melting point | 95-98°C |
|---|---|
| Boiling point | 996.2±75.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.40±0.70(Predicted) |
| color | Off-White to Pale Yellow |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373-H400 |
| Precautionary statements | P273-P391-P501-P260-P314-P501 |
42-(Dimethylphosphinate)rapamycin Chemical Properties,Uses,Production
Description
MK-8669 is a rapamycin analog that selectively inhibits mTOR (IC50 = 0.2 nM). Like rapamycin, MK-8669 binds FKBP12 to form a complex that associates with the FKBP-rapamycin binding domain on mTOR and allosterically inhibits mTORC1 kinase activity. MK-8669 is more water soluble than rapamycin and is amenable to oral or intravenous administration. Formulations containing rapalogs, including MK-8669, have promise against a subset of cancers, including advanced kidney cancer. MK-8669 is also being examined for effectiveness against cancers when used in combination with other chemotherapeutic compounds.
Chemical Properties
Off-White Solid
Definition
ChEBI: A semisynthetic derivative that is sirolimus in which hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding dimethylphosphinate.
42-(Dimethylphosphinate)rapamycin Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 139)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9336 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7121 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23555 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
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(1R,2R,4S)-4-((R)-2-((3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-Dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontin-3-yl)propyl)-2-methoxycyclohexyl dimethylphosphinate
572924-54-0
C53H84NO14P
Akt
mTOR
PI3K
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
API