ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >mTOR inhibitors >42-(Dimethylphosphinate)rapamycin
42-(Dimethylphosphinate)rapamycin
- CAS No.
- 572924-54-0
- Chemical Name:
- 42-(Dimethylphosphinate)rapamycin
- Synonyms
- Ridaforolimus;Deforolimus;DeforoliMus API;Ridaforolimus, >RidaforoliMus, >80%;DeforoliMus(MK-8669);Deforolimus (AP23573);deforolimus 572924-54-0;Ridaforolimus (MK-8669);Deforolimus (AP23573)42-
- CBNumber:
- CB72462148
- Molecular Formula:
- C53H84NO14P
- Molecular Weight:
- 990.21
- MOL File:
- 572924-54-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/17 18:22:24
| Melting point | 95-98°C |
|---|---|
| Boiling point | 996.2±75.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.40±0.70(Predicted) |
| color | Off-White to Pale Yellow |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373-H400 |
| Precautionary statements | P273-P391-P501-P260-P314-P501 |
42-(Dimethylphosphinate)rapamycin Chemical Properties,Uses,Production
Description
MK-8669 is a rapamycin analog that selectively inhibits mTOR (IC50 = 0.2 nM). Like rapamycin, MK-8669 binds FKBP12 to form a complex that associates with the FKBP-rapamycin binding domain on mTOR and allosterically inhibits mTORC1 kinase activity. MK-8669 is more water soluble than rapamycin and is amenable to oral or intravenous administration. Formulations containing rapalogs, including MK-8669, have promise against a subset of cancers, including advanced kidney cancer. MK-8669 is also being examined for effectiveness against cancers when used in combination with other chemotherapeutic compounds.
Chemical Properties
Off-White Solid
Definition
ChEBI: A semisynthetic derivative that is sirolimus in which hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding dimethylphosphinate.
42-(Dimethylphosphinate)rapamycin Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 149)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29857 | 58 | Inquiry |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2930 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7905 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23541 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 22855 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | China | 52849 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10473 | 58 | Inquiry |
572924-54-0(42-(Dimethylphosphinate)rapamycin)Related Search:
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RIDAFOROLIMUS DRUG SUBSTANCE
(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28Z,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,
572924-54-0
C53H84NO14P
Akt
mTOR
PI3K
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
API