PF-562271
- CAS No.
- 717907-75-0
- Chemical Name:
- PF-562271
- Synonyms
- CS-17;CS-2148;PF 562271;PF-00562271;PF-562271, >=98%;PF-562271 ，S2890;PF562271/PF-562271;PF-562271 free base;PF-562271 USP/EP/BP;PF-562271, 10 mM in DMSO
- CBNumber:
- CB72484683
- Molecular Formula:
- C21H20F3N7O3S
- Molecular Weight:
- 507.49
- MOL File:
- 717907-75-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2026/7/27 17:00:41
| Melting point | >204°C (dec.) |
|---|---|
| Density | 1.540 |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | White powder. |
| pka | 13.66±0.20(Predicted) |
| color | White to Off-White |
| InChIKey | MZDKLVOWGIOKTN-UHFFFAOYSA-N |
| SMILES | CS(N(C1=NC=CC=C1CNC1C(C(F)(F)F)=CN=C(NC2C=CC3=C(C=2)CC(=O)N3)N=1)C)(=O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
PF-562271 price
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PF-562271 Chemical Properties,Uses,Production
Uses
A potent, ATP-competitive and reversible inhibitor of FAK and Pyk2 catalytic activity with IC50s of 1.5 nM and 14 nM, respectively.
Enzyme inhibitor
This potent, yet reversible ATP-competitive protein kinase inhibitor (FWfreebase = 507.49 g/mol; CAS 717907-75-0; FWHCl-Salt = 543.95 g/mol; FW = 665.66 g/mol (benzenesulfonate salt); CAS 939791-38-5), also named, N- [3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4- pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide, targets Focal Adhesion Kinase, or FAK, (IC50 = 1.5 nM), with about 10x greater potency than for Pyk2 (IC50 = 14 nM) and >100x more than for other protein kinases. PF-562271 binds within the ATP-binding cleft of FAK, where it forms two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the protein kinase’s hinge region. Mode of Inhibitory Action: Many cancer cells grow in an anchorage-independent manner, and the nonreceptor tyrosine kinase FAK is thought to contribute to this phenotype by localizing in focal adhesion plaques and has playing roles as a scaffolding and signaling component. Integrin signals within the tumor microenvironment also affect cancer cell survival and invasion during tumor progression, and FAK is activated by b-integrins in both normal and transformed cells. PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (calculated EC50 = 93 ng/mL) after p.o. administration to tumor-bearing mice. PF-562271 also has potent effects on metastatic prostate cancer growth in vivo. Oral administration of PF-562271 at a dose of 5 mg/kg suppressed the growth and local spread of intratibial tumors and restored tumor-induced bone loss. The unique ability of PF-562271 to both curb tumor growth and safely increase bone formation may be an effective therapy for many cancer patients with bone metastases and cancer-associated osteoporosis.
PF-562271 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6053 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32997 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | China | 49906 | 58 | Inquiry | |
| career henan chemical co | +86-0371-86658258 | China | 29780 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | United States | 32431 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 29089 | 58 | Inquiry |
| BOC Sciences | 16314854226; +8616314854226 | United States | 19852 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | China | 10378 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6378 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11674 | 58 | Inquiry |
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