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Calcium folinate
- CAS No.
- 1492-18-8
- Chemical Name:
- Calcium folinate
- Synonyms
- LEUCOVORIN CALCIUM;Calcium Folinate Hydrate;Folinic acid calcium salt;CALCIUM LEUCOVORIN;(6R,S)-5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt;Leucovorine;Wellcovorin;FOLINIC ACID CALCIUM;N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]-L-glutamic acid calcium salt;5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt
- CBNumber:
- CB7278842
- Molecular Formula:
- C20H25CaN7O7
- Molecular Weight:
- 515.54
- MOL File:
- 1492-18-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | >300°C |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Sparingly soluble in water, practically insoluble in acetone and in ethanol (96 per cent). |
| form | powder |
| color | Pale Yellow to Light Yellow |
| BRN | 5723924 |
| BCS Class | 1 |
| Stability | Hygroscopic |
| InChIKey | SFFPBUMPHJUNTG-OKWBDBCSNA-N |
| SMILES | C(N1C(CNC2NC(N)=NC(=O)C1=2)CNC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1)=O.[Ca] |&1:22,r| |
| LogP | -3.187 (est) |
| CAS DataBase Reference | 1492-18-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 26-36-36/37-22-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MA0600500 | |||||||||
| F | 3-8-10-23 | |||||||||
| HS Code | 29362900 | |||||||||
| NFPA 704 |
|
Calcium folinate price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F7878 | Folinic acid calcium salt hydrate analytical standard | 1492-18-8 | 100MG | ₹13119.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F7878 | Folinic acid calcium salt hydrate analytical standard | 1492-18-8 | 500MG | ₹33265.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1541 | Leucovorin Calcium Pharmaceutical Secondary Standard; Certified Reference Material | 1492-18-8 | 1G | ₹9926.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F7878 | Folinic acid calcium salt hydrate analytical standard | 1492-18-8 | 1G | ₹62698.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 47612 | Folinic acid calcium salt hydrate BioXtra, ≥99.0% (HPLC) | 1492-18-8 | 250MG | ₹12264.73 | 2022-06-14 | Buy |
Calcium folinate Chemical Properties,Uses,Production
Chemical Properties
Light yellow to yellow solid
Uses
antianemic, antidote to folic acid antagonists.
Calcium folinate (folinic acid, calcium leucovorin, tetrahydrofolate) can be used in the management of methotrexate overdose and to reduce the toxicity of high-dose methotrexate chemotherapy.Calcium folinate is a reduced form of folic acid, which bypasses the inhibition of dihydrofolate reductase by methotrexate.Calcium folinate also has a role in combination with fluorouracil in the treatment of bowel cancer, where its use enhances the effect of fluorouracil by inhibition of thymidilate synthase.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Mechanism of action
The mechanism of action of Calcium folinate against cancer is to stabilise the complex between 5-FU and thymidylate synthase, thereby enhancing the cytotoxicity of 5-FU, a pyrimidine analogue and inhibitor of thymidylate synthase, which blocks DNA production. Thymidylate synthase converts deoxyuridine monophosphate to thymine monophosphate. Administration of 5-FU reduces deoxythymidine monophosphate, preventing DNA synthesis and leading to cell death.
Calcium folinate Preparation Products And Raw materials
Global( 466)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Panvo Organics Pvt Ltd | +91 9789806833 +91 9444351711 | Tamil Nadu, India | 23 | 58 | Inquiry |
| Global Calcium Pvt Ltd | +91-8050750904 +91-8040554500 | Karnataka, India | 132 | 58 | Inquiry |
| Sakar Healthcare | +91-8976292690 +91-9967572302 | Gujarat, India | 47 | 58 | Inquiry |
| Maithri Drugs Pvt Ltd | +91-9059204566 +91-9848881740 | Telangana, India | 64 | 58 | Inquiry |
| Anthem Biosciences Pvt Ltd | +91-8066724000 +91-9900044575 | Karnataka, India | 38 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Greenwell Pharma | 08046068140 | Mumbai, India | 4 | 58 | Inquiry |
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1492-18-8(Calcium folinate)Related Search:
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FOLINIC ACID, CALCIUM SALT UPS28
Calcium folinate, Leucovorine calcium
Folinic acid calcium salt >97.5%
calcium5-formyltetrahydrofolate
calciumsalt(1:1),l-yl)methyl)amino)benzoyl)
CF-CA
glutamicacid,n-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridin
lederfoline
Calcium folinatc (Leucovorin Calcium)
Calcium Leucoverin
Folinic acid hydrate calcium salt
Calcium L-folinate
Glutamic acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridinyl)methyl) amino)benzoyl)-, calcium salt (1:1), L-
N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxypteridin-6-yl)methyl]amino]benzoyl]-L-glutamic acid calcium salt
CALCIUM FOLINATE(FOLINIC ACID)(SH)
Folic Acid Related Compound A (50 mg) (Calcium Formyltetrahydrofolate)
Leucovorin Calcium (500 mg)K0F0330.998mg/mg(an)
Leucovorin Calcium (500 mg)
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt
5-HCO-H4PteGlu
Citrovorum factor calcium salt
5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium
salt
Folinic Acid CalciuM Salt (sell C0147)
CalciuM folinatc (Leucovorin CalciuM) API
Folinic acid calciuM salt (Leucovorin)
Ca folinate
Leuovorin calcium
Leucovorin Calcium/Calcium folinate
(2R)-2-{[4-({[(6R)-2-aMino-5-forMyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]Methyl}aMino)phenyl]forMaMido}pentanedioic acid
CalciuM folinate
Folinic acid calciuM salt hydrate
Folic Acid Related
Folic Acid Related CoMpound A
Folinic acid calciuM salt
CalciuM 5-forMyltetrahydrofolate
CalciuM L-folinate
CalciuM folinate
CalciuM leucovorin
Folidan
Folic Acid Related CoMpound A
leucovorincalciumsalt
5-FORMLYL-5,6,7,8-TETRAHYDROFOLIC ACID, CALCIUM SALT
CALCIUM FOLINATE
calcium (2s)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
CITROVORUM FACTOR
n-(4-(((2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-l-glutamic acid calcium salt
N5-FORMYL-5,6,7,8-TETRA-HYDROPTEROYL-L-GLUTAMIC ACID
N5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT
L-Calcium Folinate
Folinic acid calcium salt hydrate
LeucovorinCalciumGmp/EdmfUsp28
Calcium Levofolinate 80433-71-2 /
Leucovorin Calcium Gmp/Edmf
L-Glutamic acid, N-4-(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methylaminobenzoyl-, calcium salt (1:1)
LEUCOVORINCALCIUM,USP
Folinic acid ( Leucovorin Calcium)
calcium salt , l-yl)methyl) amino)benzoyl)
Leucovorin Calcium (1358004)
99.0% (HPLC)
Calcium FolinateQ: What is
Calcium Folinate Q: What is the CAS Number of
Calcium Folinate Q: What is the storage condition of
Calcium Folinate Q: What are the applications of
Calcium Folinate
Calcium folinate for system suitability(Y0002071)Q: What is
Calcium folinate for system suitability(Y0002071) Q: What is the CAS Number of
Calcium folinate for system suitability(Y0002071)
Calcium folinate (C0250000)Q: What is
Calcium folinate (C0250000) Q: What is the CAS Number of
Calcium folinate (C0250000)
Calcium folinate USP/EP/BP
Folic Acid USP RC A (Ca)
Folic Acid USP RC A