2-IMINOTHIOLANE
- CAS No.
- 4781-83-3
- Chemical Name:
- 2-IMINOTHIOLANE
- Synonyms
- 2-IMINOTHIOLANE HYDROCHLORIDE;TRAUT'S REAGENT;Nsc340007;2-Iminothiolane ,98%;dihydrothiophen-2(3H)-iMine;2-IMINOTHIOLANE;thiolan-2-iMine;2-IMINOTHIOLANE HCL;IMinothiolane hydrochlorid;2-THIOLANIMINE HYDROCHLORIDE
- CBNumber:
- CB7373482
- Molecular Formula:
- C4H7NS.ClH
- Molecular Weight:
- 137.63
- MOL File:
- 4781-83-3.mol
- Modify Date:
- 2024/7/18 18:48:51
| Melting point | 198-201 °C(lit.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 100 mg/mL |
| form | powder |
| color | White to Off-White |
| Water Solubility | Freely soluble in water |
| BRN | 3620079 |
| CAS DataBase Reference | 4781-83-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 1-3-10 |
| HS Code | 29349990 |
2-IMINOTHIOLANE price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I6256 | 2-Iminothiolane hydrochloride ≥98% (TLC), powder | 4781-83-3 | 100MG | ₹4957.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I6256 | 2-Iminothiolane hydrochloride ≥98% (TLC), powder | 4781-83-3 | 500MG | ₹16291.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I6256 | 2-Iminothiolane hydrochloride ≥98% (TLC), powder | 4781-83-3 | 1G | ₹20372.65 | 2022-06-14 | Buy |
| ALFA India | ALF-J60131-MD | 2-Iminothiolane hydrochloride | 4781-83-3 | 250mg | ₹9547 | 2022-05-26 | Buy |
| ALFA India | ALF-J60131-03 | 2-Iminothiolane hydrochloride | 4781-83-3 | 1g | ₹19128 | 2022-05-26 | Buy |
2-IMINOTHIOLANE Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Uses
2-Iminothiolane hydrochloride is a valuable tool in studies of cellular organelles and oligomeric enzymes, using the techniques of protein-protein cross-linking. It may also be used to introduce reactive sulfhydryl groups into proteins for subsequent reaction with alkylating agents or heavy metal compounds.
General Description
2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent, is commonly employed to attach thiol groups to proteins and peptides. Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.
Purification Methods
Recrystallise the hydrochloride from MeOH/Et2O (m 187-192o) or (MeOH/Me2CO), but after sublimation at ~180o/0.2mm the melting point rises to 202-203o. It has 1HNMR with 2.27 (2H, t), 3.25 (2H, t) and 3.52 (2H, t) in (CD3)2SO. [King et al. Biochemistry 17 1499 1978.] The free base is purifed by vacuum distillation (b 71-72o/6mm) with IR (film) with 1700 (C=N)cm-1 and 1HNMR (CDCl3) with at 3.58 (2H, t) and max 2.10-2.8 (4H, m). The free base is stable on storage but slowly hydrolyses in aqueous solutions with half-lives at 25o of 390hours at pH 9.1, 210hours at pH 10 and 18hours at pH 11. [Traut et al. Biochemistry 12 3266 1973, Biochemistry 17 399 1978, Alagon & King Biochemistry 19 4343 1980, Beilstein 17/9 V 12.]
2-IMINOTHIOLANE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | China | 3002 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | CHINA | 21149 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |