VENTURICIDIN A

VENTURICIDIN A Structure
CAS No.
33538-71-5
Chemical Name:
VENTURICIDIN A
Synonyms
a-130;aa-0368;venturicidinb,3’-carbamate;HHQKNFDAEDTRJK-WLJINWSWSA-N;4,21-Dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one, 11-[[3-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,18-tetramethyl-, (1R,5S,6R,8R,9E,11R,15E,17R)-
CBNumber:
CB7505296
Molecular Formula:
C41H67NO11
Molecular Weight:
749.97
MOL File:
33538-71-5.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:04

VENTURICIDIN A Properties

Melting point 145-147°; mp 140-142°
alpha D +119° (c = 0.5 in chloroform)
Boiling point 874.9±65.0 °C(Predicted)
Density 1.16±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
pka 11.80±0.70(Predicted)
form White to off-white solid.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P271-P261-P280
RTECS  YX4556000
HS Code  2941900000

VENTURICIDIN A Chemical Properties,Uses,Production

Description

Venturicidin A is a macrolide antibiotic isolated from strains of Streptomyces. It is active against fungi in the genus Venturia which cause apple scab, as well as other fungi, but not against higher plants. Venturicidin A is also cytotoxic against trypanosomes (IC50 = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells. It inhibits bacterial and mitochondrial ATP synthases.

Uses

The macrolide antibiotic, Venturicidin A, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin A was originally isolated as an antifungal agent.

VENTURICIDIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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a-130 aa-0368 venturicidinb,3’-carbamate HHQKNFDAEDTRJK-WLJINWSWSA-N 4,21-Dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one, 11-[[3-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,18-tetramethyl-, (1R,5S,6R,8R,9E,11R,15E,17R)- 33538-71-5 C41H67NO11 Antibiotic