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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Structure
CAS No.
105628-72-6
Chemical Name:
1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
Synonyms
Ha 1100;Fasudil Impurity L;Fasudil Impurity 5;1-[(1,2-DIHYDRO-1-OX;HA 1100 HYDROCHLORIDE;HA-1100;HA 1100;HA1100;HYDROXYFASUDIL;HA-1100;HA 1100;HA1100;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol;5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1(8aH)-one
CBNumber:
CB7847446
Molecular Formula:
C14H17N3O3S
Molecular Weight:
307.37
MOL File:
105628-72-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:17
Request For Quotation

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Properties

storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Toxicity mouse,LD50,unreported,145mg/kg (145mg/kg),United States Patent Document. Vol. #4678783,

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Chemical Properties,Uses,Production

Biological Activity

Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Preparation Products And Raw materials

Raw materials

Preparation Products

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Suppliers

Global( 84)Suppliers
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ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
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Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
ANHUI WITOP BIOTECH CO., LTD 58
Finetech Industry Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
GIHI CHEMICALS CO.,LIMITED 58
China National Standard Pharmaceutical Corporation Limited 58
Aladdin Scientific 58

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Spectrum

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE(105628-72-6)1HNMR

105628-72-6(1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE)Related Search:

5-Quinolinesulfonic acid, 2-methyl- Fasudil Impurity 6 Fasudil Impurity 13 Fasudil Pyridine N-Oxide TFA Salt Fasudil Impurity 9
Fasudil Impurity 34 Fasudil iMpurity Fasudil Impurity 7 1-[(1-Chloro-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Fasudil Impurity 8
1-Chloro-5-isoquinolinesulfonic Acid Fasudil Impurity 6 1,4-ditosyl-1,4-diazepane Fasudil diMer Fasudil N-hydroxy iMpurity
N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE Isoquinoline HYDROXYFASUDIL MONOHYDROCHLORIDE
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5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one HYDROXYFASUDIL;HA-1100;HA 1100;HA1100 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE 1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)- Ha 1100 Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride HA 1100 HYDROCHLORIDE 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol Fasudil Impurity L 1-[(1,2-DIHYDRO-1-OX 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one Fasudil impurity 12/5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one hydrochloride HA-1100;HA 1100;HA1100 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]- 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1(8aH)-one HA1100,ROCK,Rho-kinase,inhibit,Rho-associated kinase,Inhibitor,ROK,Hydroxyfasudil,HA 1100,Rho-associated protein kinase Fasudil Impurity 5 105628-72-6 C14H17N3O3S Angiogenesis and Metastasis Intracellular signaling