laudanosine

CAS No.: 2688-77-9

Chemical Name:: laudanosine

Synonyms: Nsc 35045;Einecs 220-253-2;(+)-(S)-Laudanosine;Cisatracurium Besylate Impurity 49;(S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline;(1S)-1,2,3,4-Tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinoline;[1S,(+)]-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline;Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-

CBNumber:: CB7897724

Molecular Formula:: C21H27NO4

Molecular Weight:: 357.44

MOL File:: 2688-77-9.mol

Modify Date:: 2023/6/8 9:02:58

Request For Quotation

laudanosine Properties

Melting point	89°
alpha	D16 +106° (c = 1.6 in 97% alc); D16 +130° (chloroform); D22 +52.2 ±1.3° (chloroform); D20 +82.5° (ethanol)
Boiling point	490.07°C (rough estimate)
Density	1.1729 (rough estimate)
refractive index	1.5614 (estimate)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)
form	White to Pale Beige
pka	7.80±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

NFPA 704

	0
4		0

laudanosine Chemical Properties,Uses,Production

Uses

Laudanosine is a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.

Purification Methods

Crystallise these from EtOH. The (±)-picrate crystallises from EtOH with m 177-178o. The (-)-isomer has m 83-85o and

laudanosine Preparation Products And Raw materials

Raw materials

(R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline DL-LAUDANOSINE 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline Formaldehyde

Preparation Products

laudanosine Suppliers

Global( 25)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	China	17995	56	Inquiry
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	China	7980	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	China	8739	58	Inquiry
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd	18502726233; 18502726233	China	9805	58	Inquiry
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	China	5588	58	Inquiry
Regis Technologies, Inc.	847 967 6000	United States	148	71	Inquiry
American Custom Chemicals Corporation	858 201 6118	United States	6826	51	Inquiry
Apin Chemicals Limited (UK)	+44 1235 832515	United Kingdom	6188	60	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
ChemStrong Scientific Co.,Ltd	56
Shanghai Yiyan Biotechnology Co. , Ltd.	58
Cayman Chemical Company	81
Shanghai Yifei Biotechnology Co. , Ltd.	58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd	58
Nanjing Tengyi Biotechnology Co., Ltd	58
Regis Technologies, Inc.	71
American Custom Chemicals Corporation	51
Apin Chemicals Limited (UK)	60

2688-77-9(laudanosine )Related Search:

Cisatracurium Besilate EP Impurity W Iodide (Mixture of Diastereomers) Cisatracurium Besilate EP Impurity N and O Iodide (Mixture of Diastereomers) Atracurium EP Impurity D Iodide (Mixture of Diastereomers) Atracurium Impurity 1 (R-trans, R-trans)-AtracuriuM Besylate

PHENYL P-TOLYL SULFONE Atracurium Impurity 27 Besylate Atracurium EP Impurity K Iodide (Mixture of Diastereomers) Atracurium Impurity 15 Atracurium Impurity 19

AtracuriuM IMpurity A1 (trans-Monoquatenary) Atracurium Impurity 34 Iodide Cisatracurium Besilate EP Impurity T Iodide Atracurium Impurity 30 Besylate Atracurium Impurity 12 Iodide (Mixture of Diastereomers)

Atracurium Impurity 24 1-(3,4-dimethoxy-benzyl)-7,8-dimethoxy-1,2,3,4-tetrahydro-isoquinoline Atracurium Impurity 37 Besylate

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Nsc 35045 (+)-(S)-Laudanosine (1S)-1,2,3,4-Tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinoline [1S,(+)]-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline Einecs 220-253-2 Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)- (S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline Cisatracurium Besylate Impurity 49 2688-77-9 Alkaloids Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Aromatics, Chiral Reagents, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals