Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >HDAC inhibitors >ACY-1215

ACY-1215

ACY-1215 Structure
CAS No.
1316214-52-4
Chemical Name:
ACY-1215
Synonyms
ACY 63;CS-583;ACY-1215;Propane-1;Ricolinostat;Rocilinostat;ACY-1215/ACY1215;Rocilinostat, >=99%;3-tricarboxylic acid;β-Carboxyglutaric acid
CBNumber:
CB82627292
Molecular Formula:
C24H27N5O3
Molecular Weight:
433.5
MOL File:
1316214-52-4.mol
MSDS File:
SDS
Modify Date:
2023/8/29 17:14:30
Request For Quotation

ACY-1215 Properties

Melting point 189 - 191°C
Density 1.239±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
pka 9.47±0.20(Predicted)
form Solid
color White to Off-White

ACY-1215 Chemical Properties,Uses,Production

Description

ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM). It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis. ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts. A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide and dexamethasone in multiple myeloma found inhibition of HDAC6 in vivo. ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.

Uses

This compound acts as a selective HDAC-6 (histone deacetylase) inihibitor. HDAC is linked to the transcription of DNA in cancers, including multiple myeloma (MM).

ACY-1215 Preparation Products And Raw materials

Raw materials

Preparation Products

ACY-1215 Suppliers

Global( 166)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Shaanxi Haibo Biotechnology Co., Ltd +undefined18602966907 China 1000 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
CD Chemical Group Limited +8615986615575 China 20356 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Shaanxi Haibo Biotechnology Co., Ltd 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
TargetMol Chemicals Inc. 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
CD Chemical Group Limited 58
InvivoChem 58

ACY-1215 Spectrum

ACY-1215(1316214-52-4)1HNMR

1316214-52-4(ACY-1215)Related Search:

Panobinostat Mocetinostat (MGCD0103) Tubastatin-A Tubastatin A hydrochloride Entinostat
Crizotinib
chevron_left

1of2

chevron_right
Rocilinostat (ACY-1215) 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide ACY 63 2-(DiphenylaMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide Rocilinostat, >=99% 5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]- 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide ACY 1215 Ricolinostat N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide Parathyroid hormone - Shire ACY-1215 Rocilinostat ACY-1215 (Rocilinostat) ACY-1215/ACY1215 RICOLINOSTAT;ACY1215;ACY 1215 Ricolinostat (ACY-1215) CS-583 ROCILINOSTAT; ACY1215; ACY 1215;RICOLINOSTAT 1316214-52-4 ACY1215,ROCILINOSTAT 7-{[2-(Diphenylamino)pyrimidin-5-yl]formamido}-N-hydroxyheptanamide 3-tricarboxylic acid Propane-1 β-Carboxyglutaric acid ACY-1215 ACY-63 Ricolinostat ACY1215 2- (Diphenylamino) - N - [7- (hydroxyamino) -7-oxoheptyl] -5-pyrimidine carboxylamide 1316214-52-4 Inhibitors Inhibitor