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PPQ-102

PPQ-102 Structure
CAS No.
931706-15-9
Chemical Name:
PPQ-102
Synonyms
PPQ-102;CS-1365;CFTR Inhibitor;PPQ 102, >=98%;PPQ-102, CFTR Inhibitor;CFTR INHIBITOR; PPQ102; PPQ 102;CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem;7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione;7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE
CBNumber:
CB82628279
Molecular Formula:
C26H22N4O3
Molecular Weight:
438.48
MOL File:
931706-15-9.mol
Modify Date:
2024/7/2 8:55:20
Request For Quotation

PPQ-102 Properties

Melting point >300℃ (ethanol )
Boiling point 648.7±65.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. -20C
solubility DMF: 0.2 mg/ml
form White crystalline solid
pka 1.00±0.40(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280-P305+P351+P338

PPQ-102 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 219677 CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem The CFTR Inhibitor IV, PPQ-102, also referenced under CAS 931706-15-9, controls the biological activity of CFTR. This small molecule/inhibitor is prim 931706-15-9 10MG ₹21460 2022-06-14 Buy
Product number Packaging Price Buy
219677 10MG ₹21460 Buy

PPQ-102 Chemical Properties,Uses,Production

General Description

A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.

PPQ-102 Preparation Products And Raw materials

Raw materials

Preparation Products

PPQ-102 Suppliers

Global( 74)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Matrix Scientific 803 788-9494 All other calls United States 6655 80 Inquiry
ShangHai Siyan Biological Technology Co., Ltd. 021-50908862，442785678，326799392 18721037013 China 9638 58 Inquiry
Angel Pharmatech, Ltd. 17317130613 China 3246 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
InvivoChem 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Matrix Scientific 80
ShangHai Siyan Biological Technology Co., Ltd. 58
Angel Pharmatech, Ltd. 58

931706-15-9(PPQ-102)Related Search:

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PPQ-102 7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE PPQ-102, CFTR Inhibitor 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione 7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione PPQ-102 PPQ-102 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione PPQ 102, >=98% CS-1365 CFTR Inhibitor CFTR INHIBITOR; PPQ102; PPQ 102 CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem Pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione, 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl- 7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione polycystic kidney disease,E13.5 embryonic kidneys,inhibit,Inhibitor,PPQ-102,CFTR,Cystic fibrosis transmembrane conductance regulator 931706-15-9 Inhibitors