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Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Structure
CAS No.
325970-71-6
Chemical Name:
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
Synonyms
L67 >=98% (HPLC);DNA LIGASE INHIBITOR; L-67; L 67;Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
CBNumber:
CB82668145
Molecular Formula:
C16H14Br2N4O4
Molecular Weight:
486.11
MOL File:
325970-71-6.mol
Modify Date:
2024/7/2 8:55:20
Request For Quotation

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Properties

storage temp. Store at -20°C
solubility DMSO:21.5(Max Conc. mg/mL);44.23(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);20.57(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);2.06(Max Conc. mM)
form A crystalline solid
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H361-H372-H410
Precautionary statements  P201-P264-P280-P301+P330+P331-P312

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Chemical Properties,Uses,Production

Description

L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 μM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 μM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 μM.

Uses

L 67 is used in the identification and validation of human DNA ligase inhibitors using computer-aided grug design.

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Preparation Products And Raw materials

Raw materials

3,5-DIBROMO-4-METHYLANILINE 5-Nitrosalicylaldehyde

Preparation Products

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Suppliers

Global( 38)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
AdooQ Bioscience CHINA 025-58849295 18951903616; China 2989 60 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
MedChemExpress 021-58955995 United States 6398 58 Inquiry
Shanghai tingchong biology science and technology co., ltd 18964309092 18964309092 China 2635 58 Inquiry
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 China 11289 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
AdooQ Bioscience CHINA 60
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
MedChemExpress 58
Shanghai tingchong biology science and technology co., ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide DNA LIGASE INHIBITOR; L-67; L 67 L67 >=98% (HPLC) 325970-71-6 C16H14Br2N4O4