ChemicalBook > Product Catalog >Analytical Chemistry >Standard >Pharmaceutical Impurity Reference Standards >2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester

2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester

2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester Structure
CAS No.
320347-97-5
Chemical Name:
2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester
Synonyms
GYDFTKNRHZMENP-ZDUSSCGKSA-N;Tiotropium Bromide Impurity 2;Aclidinium Bromide Impurity 5;Tiotropium bromide Impurity 18;(R)-Quinucldin-3-yl hydroxybis(2-thienyl)acetate;(R)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate;2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester;2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester;2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester-5
CBNumber:
CB82668165
Molecular Formula:
C17H19NO3S2
Molecular Weight:
349.46
MOL File:
320347-97-5.mol
Modify Date:
2023/7/1 8:28:08

2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester Properties

Melting point 180℃ (isopropyl ether )
Boiling point 513.3±50.0 °C(Predicted)
Density 1.40±0.1 g/cm3(Predicted)
pka 10.33±0.29(Predicted)

2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester Chemical Properties,Uses,Production

Uses

(R)-3-Quinuclidinyl di(2-thienyl)glycolate acts as a potent and long-acting muscarinic antagonist with minimal systemic exposure after inhalation. Used in the treatment of chronic obstructive pulmonary disease.

2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester Preparation Products And Raw materials

Raw materials

Preparation Products

2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester (R)-Quinucldin-3-yl hydroxybis(2-thienyl)acetate 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester-5 Aclidinium Bromide Impurity 5 Tiotropium Bromide Impurity 2 (R)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester Tiotropium bromide Impurity 18 GYDFTKNRHZMENP-ZDUSSCGKSA-N 320347-97-5