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Loxoprofen

Loxoprofen Structure
CAS No.
68767-14-6
Chemical Name:
Loxoprofen
Synonyms
IOXOPROFEN;2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid;2-[4-(2-OXO-CYCLOPENTYLMETHYL)-PHENYL]-PROPIONIC ACID;A-METHYL-4-[(2-OXOCYCLOPENTYL)METHYL]BENZENEACETIC ACID;KOLOXO;LOXOPROFEN;Loxoprofene;Loxoprofeno;Loxoprofen-d6;Loxoprofen RS
CBNumber:
CB8311755
Molecular Formula:
C15H18O3
Molecular Weight:
246.31
MOL File:
68767-14-6.mol
Modify Date:
2024/4/16 13:12:53

Loxoprofen Properties

Melting point 108.5-111°
Boiling point bp0.3 190-195°
Density 1.182±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form solid
pka 4.39±0.10(Predicted)
color White to Off-White
Merck 14,5589
InChI InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)
InChIKey YMBXTVYHTMGZDW-UHFFFAOYSA-N
SMILES C(C1CCCC1=O)C1C=CC(C(C)C(=O)O)=CC=1
CAS DataBase Reference 68767-14-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3
HS Code  2918.99.3000

Loxoprofen price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) L0664 Loxoprofen solid 68767-14-6 5MG ₹36187.98 2022-06-14 Buy
TCI Chemicals (India) L0244 Loxoprofen 68767-14-6 5G ₹9600 2022-05-26 Buy
Product number Packaging Price Buy
L0664 5MG ₹36187.98 Buy
L0244 5G ₹9600 Buy

Loxoprofen Chemical Properties,Uses,Production

Uses

Loxoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. Loxoprofen becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.

Definition

ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted to its active trans-alcohol metabolite following ora administration.

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2-[4-[(2-Oxocyclopentan-1-yl)methyl]phenyl]propionic acid KOLOXO LOXOPROFEN α-methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid ALPHA-METHYL-4-[(2-OXOCYCLOPENTYL)METHYL]BENZENEACETIC ACID Benzeneacetic acid, a-methyl-4-[(2-oxocyclopentyl)methyl]- (9CI) Loxoprofen (base and/or unspecified salts) α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid, Koloxo Loxoprofen (high-melting polymorph) Loxoprofen (low-melting polymorph) 2-[p-(2-Oxocyclopentylmethyl)phenyl]propionic acid 2-[4-[(2-ketocyclopentyl)methyl]phenyl]propionic acid Loxoprofen USP Loxoprofen See L472900 Benzeneacetic acid, a-Methyl-4-[(2-oxocyclopentyl)Methyl]- Loxoprofen-d6 Loxoprofen RS Loxoprofene Loxoprofeno Benzeneacetic acid, α-methyl-4-[(2-oxocyclopentyl)methyl]- Loxoprofen USP/EP/BP Loxoprofen (10mM in DMSO) Loxoprofen Impurity 67 Loxoprofen Impurity 68 Loxoprofen-d3Q: What is Loxoprofen-d3 Q: What is the CAS Number of Loxoprofen-d3 Loxoprofen D7 Loxoprofen API 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid 2-[4-(2-OXO-CYCLOPENTYLMETHYL)-PHENYL]-PROPIONIC ACID IOXOPROFEN A-METHYL-4-[(2-OXOCYCLOPENTYL)METHYL]BENZENEACETIC ACID Benzeneacetic acid, α-methyl-4-[(2-oxocyclopentyl)methyl]- 2-(4-((2-(hydroxymethyl)-1,4-dioxaspiro[4.4]nonan-6-yl)methyl)phenyl)propanoic acid 68767-14-6 LOXONIN Active Pharmaceutical Ingredients