D-GALACTOSAMINE

CAS No.: 7535-00-4

Chemical Name:: D-GALACTOSAMINE

Synonyms: C02262;D-Chondrosamine;D-GALACTOSAMINE;d-2-amino-2-deoxygalactose;D-Galactose, 2-amino-2-deoxy-;(2R,3R,4R,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal

CBNumber:: CB8389318

Molecular Formula:: C6H13NO5

Molecular Weight:: 179.17

MOL File:: 7535-00-4.mol

Modify Date:: 2022/12/21 16:56:50

Request For Quotation

D-GALACTOSAMINE Properties

Melting point	185 °C
Boiling point	532.5±50.0 °C(Predicted)
Density	1.491±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	11.21±0.45(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317-H319
Precautionary statements	P280-P305+P351+P338

D-GALACTOSAMINE Chemical Properties,Uses,Production

Description

Galactosamine is a model hepatotoxicant, induces hepatitis characterized by neutrophilic infiltration, and kills the animal by fulminant hepatic failure. Galactosamine, an amino derivative of sugar galactose, has been used as a model hepatotoxicant since the first reports of hepatotoxicity in late 1970s by Keppler and associates. Galactosamine-induced hepatitis has been a model of choice to study various aspects of liver disease, including mechanisms of toxicant-induced apoptosis and necrosis, liver tissue repair, neutrophil infiltration and transmigration, and the role of endotoxin or lipopolysaccharide (LPS) in initiating liver injury.
Humans and animals synthesize galactosamine in the body. Galactosamine (a type of hexosamine) is formed when an amino group replaces one of the hydroxy groups of a sixcarbon sugar, or hexose. The human body utilizes uridine diphosphate (UDP)-N-acetyl-D-glucosamine or glucosamine as a precursor to synthesize this compound, and is most often found in the form N-acetyl-D-galactosamine (often referred to as N-acetylgalactosamine). Most importantly, galactosamine is a constituent of hyaluronic acid, a powerful water-binding agent. Many different types of tissues in human body contain hyaluronic acid, which acts as a lubricating agent in the synovial fluid of joints and in connective tissues. Hyaluronic acid also acts as a lubricating agent in the vitreous humor of the eyeball. Hyaluronic acid has considerable medicinal value; it is often used in wound healing, burn dressings, osteoarthritis treatment, cataract or corneal transplantation surgery, and various types of plastic surgeries.

Definition

ChEBI: The pyranose form of D-galactosamine.

Toxicity evaluation

Galactosamine induces liver injury by interfering with the uridine pool in the cell, which is essential for RNA and protein synthesis. Galactosamine ismetabolized via the Leloir pathway of galactose metabolism, which leads to the generation of uridine derivatives of galactosamine. The two enzymes of the Leloir pathway, galactokinase and UDP-galactose uridyltransferase, convert galactosamine into galactosamine-1-phosphate and UDP-galactosamine, respectively,due to their lowsubstrate specificity.UDPgalactosamine blocks the final enzyme in Leloir pathway, the UDP-galactose-40 epimerase, resulting in the accumulation of UDP-galactosamine in the cells. This results in the depletion of uridine triphosphate (UTP), UDP, uridine monophosphate (UMP), and the sugar derivative of uridine such as UDP-glucose and UDP-galactose essential for RNA and protein synthesis. Orotate, a precursor of the hexosamine biosynthesis pathway, has been used as an antidote to galactosamine toxicity.

D-GALACTOSAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

D-GALACTOSAMINE Suppliers

Global( 26)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	China	7287	58	Inquiry
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	China	5999	58	Inquiry
Hubei Wande Chemical Co., Ltd	027-59210159 15377098680	China	9976	58	Inquiry
Hubei Guangao Biotechnology Co., Ltd	027-027-59223056 18162699093	China	9928	58	Inquiry
Shanghai Haohong Pharmaceutical Co., Ltd.	4008210725 4008210725	China	55023	58	Inquiry
Jinan Kabotang Biological Technology Co.,Ltd.	0531-61320525 15866703830	China	6838	58	Inquiry
ChemPacific Corporation	410 633 5771	United States	6902	51	Inquiry
GLYCOTEAM GmbH	+49 40 238 57911	Germany	148	46	Inquiry
APAC Pharmaceutical, LLC	+1(410) 997 5552	United States	6332	38	Inquiry
3B Scientific Corporation	847.281.9822	United States	6744	47	Inquiry

Supplier	Advantage
Jinan Carbotang Biotech Co.,Ltd.	58
Wuhan Fortuna Chemical Co., Ltd	58
Hubei Wande Chemical Co., Ltd	58
Hubei Guangao Biotechnology Co., Ltd	58
Shanghai Haohong Pharmaceutical Co., Ltd.	58
Jinan Kabotang Biological Technology Co.,Ltd.	58
ChemPacific Corporation	51
GLYCOTEAM GmbH	46
APAC Pharmaceutical, LLC	38
3B Scientific Corporation	47

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d-2-amino-2-deoxygalactose D-GALACTOSAMINE C02262 D-Chondrosamine (2R,3R,4R,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal D-Galactose, 2-amino-2-deoxy- 7535-00-4