HIRUDIN
- CAS No.
- 8001-27-2
- Chemical Name:
- HIRUDIN
- Synonyms
- hirudex;NATIVE HIRUDIN;DESULFO-HIRUDIN;DESULFATO-HIRUDIN;recombinanthirudin;HIRUDIN RECOMBINANT;hirudin from leeches;[TYR63]HIRUDIN (HV1), LEECH;Hirudin recombinant from yeast;[63-TYROSINE]HIRUDIN (HV1), LEECH
- CBNumber:
- CB8399669
- Molecular Formula:
- C287H440N80O113S7
- Molecular Weight:
- 7043.4877
- MOL File:
- 8001-27-2.mol
- Modify Date:
- 2023/4/23 13:52:06
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H334 |
| Precautionary statements | P280 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | MR8440000 |
| F | 10-21 |
| HS Code | 3504009000 |
HIRUDIN price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H0393 | Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) | 8001-27-2 | 100UNITS | ₹47727.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H0393 | Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) | 8001-27-2 | 500UNITS | ₹163035.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 94581 | Hirudin recombinant from yeast lyophilized powder, white, >1500?U/vial | 8001-27-2 | 1EA | ₹114420.25 | 2022-06-14 | Buy |
HIRUDIN Chemical Properties,Uses,Production
Description
Refludan was launched in Germany for heparin-associated thrombocytopenia. Originally isolated from the saliva of leeches (Hirudo medicinalis), the gene for recombinant hirudin was synthesized and expressed in Saccharomyces cerevisiae. The isolated protein is 65 amino acids differing from the native protein by the first two amino acids (Leu1 and Thr2) and Tyr63 is not sulfated, while it does retain the three disulfide bonds. Refludan is a potent, specific and almost irreversible inhibitor of thrombin with which it forms a 1:1 complex. The N-terminal domain binds to the active catalytic site of thrombin, while the C-terminal end binds to the anion binding exosite (fibrinogen binding cleft). It has several advantages over heparin: it can inhibit thrombin bound to extracellular matrices, does not require antithrombin Ⅲ as a cofactor, is not inhibited by activated platelet nor increases platelet activity, and is a pure, single compound with a single mechanism of action. It is useful for myocardial infarcts, unstable angia and cardiovascular events. Heparin treatment can be inhibited by platelets activated by the Fc fragment of antibodies developed to the antigen of heparin-platelet factor 4. A corresponding inactivation of Refuldan is not known.
Uses
Recombinant hirudin from yeast has been used in mannan-binding lectin serine protease 2 (MASP2) activation assay. It has also been used in pre-treating the nanosheets in phosphate buffered saline (PBS) for platelet adhesion assay.
General Description
Hirudin is a 7 kDa acidic protein containing 65 amino acid residues that has an isoelectric point of 3.5-4.0. It is not glycosylated and lacks tryptophan, arginine and methionine residues. It is chemically stable between pH 2-12 and at temperatures up to 80°C.
HIRUDIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | China | 2995 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | China | 2345 | 58 | Inquiry |
| Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 | China | 2452 | 58 | Inquiry |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | China | 7431 | 58 | Inquiry |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | China | 2605 | 58 | Inquiry |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | China | 5814 | 58 | Inquiry |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | China | 4905 | 58 | Inquiry |
| Kono Chem Co.,Ltd | 029-86107037-8009 13279399072 | China | 728 | 58 | Inquiry |
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