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Rimegepant sulfate

Rimegepant sulfate Structure
CAS No.
1374024-48-2
Chemical Name:
Rimegepant sulfate
Synonyms
RIMEGEPANT SULFATE;Rimegepant sulfate hydrate;Rimegepant 1/2Sulfate 3/2Trihydrate;Rimegepant hemisulfate sesquihydrate;[(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl]4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate;(5S,6S,9R)-5-amino-6-(2,3difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b] pyridin-9-yl4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate sesquihydrate;(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate hemisulfate sesquihydrate;Rimegepant sulfate hydrate【Chemical name：1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta;Rimegepant sulfate hydrate【Chemical name：1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester, sulfate, hydrate (2:1:3)】
CBNumber:
CB84748603
Molecular Formula:
C28H30F2N6O7S
Molecular Weight:
632.64
MOL File:
1374024-48-2.mol
Modify Date:
2024/8/5 12:01:54
Request For Quotation

Rimegepant sulfate Properties

InChIKey SBWRYPRKGHWPOH-FDZFFRPLNA-N
SMILES S(O)(O)(=O)=O.O=C1NC2=NC=CC=C2N1C1CCN(C(=O)O[C@@H]2CC[C@@H](C3C=CC=C(F)C=3F)[C@H](N)C3=CC=CN=C23)CC1 |&1:22,25,34,r|

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H373-H361d
Precautionary statements  P260-P314-P501

Rimegepant sulfate Chemical Properties,Uses,Production

Description

Rimegepant sulfate is a small molecule, highly selective calcitonin gene-related peptide antagonist (CGRP) developed by Biohaven Pharmaceutical Holdings, Inc. and approved by the FDA for the acute treatment of migraine. rimegepant and ubrogepant are the only CGRP antagonists with oral bioavailability. Because of the absence of vasoconstrictive properties observed with oral CGRP antagonists, the use of rimegepant is safer and more reliable in patients with contraindications to standard therapy[1].

Side effects

Common side effects of Rimegepant sulfate are nausea, which may be severe enough to cause shortness of breath, difficulty breathing; swelling of the face, eyes, mouth, throat, tongue, or lips; rash, measles; and itching.

Synthesis

Rimegepant sulfate is prepared by the reaction of rimegepant and water.
Step: With sulfuric acid In ethanol at 20 - 70℃; Solvent; Temperature.
Rimegepant sulfate synthesis

References

[1] J S. Rimegepant: First Approval.[J]. Drugs, 2020, 80 7: 741-746. DOI:10.1007/s40265-020-01301-3.

Rimegepant sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

Rimegepant sulfate Suppliers

Global( 81)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. +86-18600796368 +86-18600796368 China 484 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-29-81148696 +86-15536356810 China 3882 58 Inquiry
Hangzhou ICH Biofarm Co., Ltd +86-0571-28186870; +undefined8613073685410 China 1010 58 Inquiry
Jinan Carbotang Biotech Co.,Ltd. +8615866703830 China 8497 58 Inquiry
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. +86-029-86185165 +8618629664246 China 1615 58 Inquiry
SyncoZymes (Shanghai) Co., Ltd., +86-021-68187180-811 +86-13681683526 China 188 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49734 58 Inquiry
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. +86-18616643091 +86-18616643091 China 246 58 Inquiry
Shaanxi LonierHerb Bio Technology Co Ltd +86-86-+86-86-029-87551862 +8617702909819 China 2608 58 Inquiry
Changzhou AniKare Pharmatech Co., Ltd. +86-0519-8359-8696 +8618018249389 China 9896 58 Inquiry
Supplier Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 58
Shaanxi Dideu Medichem Co. Ltd 58
Hangzhou ICH Biofarm Co., Ltd 58
Jinan Carbotang Biotech Co.,Ltd. 58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. 58
SyncoZymes (Shanghai) Co., Ltd., 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. 58
Shaanxi LonierHerb Bio Technology Co Ltd 58
Changzhou AniKare Pharmatech Co., Ltd. 58

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[(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl]4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate hemisulfate sesquihydrate Rimegepant sulfate hydrate【Chemical name：1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester, sulfate, hydrate (2:1:3)】 RIMEGEPANT SULFATE (5S,6S,9R)-5-amino-6-(2,3difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b] pyridin-9-yl4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate sesquihydrate Rimegepant sulfate hydrate Rimegepant hemisulfate sesquihydrate Rimegepant 1/2Sulfate 3/2Trihydrate Rimegepant sulfate hydrate【Chemical name：1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta 1374024-48-2 API