Benzil
- CAS No.
- 134-81-6
- Chemical Name:
- Benzil
- Synonyms
- DIBENZOYL;Diphenylethane-1,2-dione;1,2-DIPHENYLETHANEDIONE;1,2-Diphenylethane-1,2-dione;BENZIL;CHC-12;Wy 20910;wy-20910;BIBENZOYL;Benzil≥98%
- CBNumber:
- CB8478221
- Molecular Formula:
- C14H10O2
- Molecular Weight:
- 210.23
- MOL File:
- 134-81-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/15 13:45:27
| Melting point | 94-95 °C(lit.) |
|---|---|
| Boiling point | 346 °C |
| Density | 1,521 g/cm3 |
| vapor pressure | 1 mm Hg ( 128.4 °C) |
| refractive index | 1.5681 (estimate) |
| Flash point | 346-348°C |
| storage temp. | Store below +30°C. |
| solubility | <0.5g/l |
| form | Crystalline Powder |
| color | White |
| Water Solubility | 0.5 g/L (20 ºC) |
| Merck | 14,1078 |
| BRN | 608047 |
| Dielectric constant | 13.0（94℃） |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | WURBFLDFSFBTLW-UHFFFAOYSA-N |
| CAS DataBase Reference | 134-81-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanedione, diphenyl-(134-81-6) |
| EPA Substance Registry System | Benzil (134-81-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DD1925000 | |||||||||
| F | 10 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29143900 | |||||||||
| Toxicity | LD50 orally in Rabbit: 2710 mg/kg | |||||||||
| NFPA 704 |
|
Benzil price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | B0050 | Benzil min. 99.0 % | 134-81-6 | 25G | ₹2000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B0221 | Benzil Zone Refined (number of passes:22) | 134-81-6 | 1SAMPLE | ₹15600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B0050 | Benzil min. 99.0 % | 134-81-6 | 500G | ₹6400 | 2022-05-26 | Buy |
| ottokemi | B 1525 | Benzil 99% | 134-81-6 | 250gm | ₹198 | 2022-05-26 | Buy |
| ottokemi | B 1525 | Benzil 99% | 134-81-6 | 500gm | ₹1692 | 2022-05-26 | Buy |
Benzil Chemical Properties,Uses,Production
Chemical Properties
yellow crystals or powder
Uses
Benzil is used as a pharmaceutical intermediate and uv curing resin photosensitizer. In polymer chemistry, it is used as a photoinitiator. Further, it serves as a potent inhibitor of human carboxylesterases. It is used in the preparation of diketimines by reacting with amines. It is also involved in the famous benil-benzilic acid rearrangement. In addition this, it reacts with 1,3-diphenylacetone to get tetraphenylcyclopentadienone.
Definition
A reaction in which benzil (1,2- diphenylethan-1,2-dione) is treated with hydroxide and then with acid to give benzilic acid (2-hydroxy-2,2-diphenylethanoic acid):
C6H5.CO.CO.C6H5→
(C6H5)2C(OH).COOH
The reaction, which involves migration of a phenyl group (C6H5-) from one carbon atom to another, was the first rearrangement reaction to be described (by Justus von Liebig in 1828).
benefits
Benzil has potential applications in biological metabolism and clinical medicine. Benzil derivates exhibit radical scavenging and antibacterial and hypertensive, antiprotozoal, antiproliferative, and antimitotic activities. Benzil derivatives have versatile applications in the pharmaceutical industry, and various heterocyclic compounds such as triazine, quinoxaline, and imidazole can be synthesized from 1,2-diketones. It is also used as a nanocatalyst in the application of imidazole derivatives. Recently, it is reported that benzil derivatives acted as photosensitive agents and photoinitiators due to its antitumor activity[1].
Safety Profile
Low toxicity by ingestion. An eyeirritant. Combustible. When heated to decomposition itemits acrid smoke and irritating fumes.
Safety
Potential Acute Health Effects: Very hazardous in case of skin contact (irritant), of eye contact (irritant). Hazardous in case of ingestion, of inhalation.
The substance is toxic to lungs, mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage. Eye Contact: Check for and remove any contact lenses.
Fine dust dispersed in air may ignite. Dust can form an explosive mixture in air. Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition.
Solubility in organics
Soluble in ethanol (50 mg/ml), chloroform, ether, and ethyl acetate. Insoluble in water.
Purification Methods
Crystallise benzil from *benzene after washing with alkali. (Crystallisation from EtOH did not free benzil from material reacting with alkali.) [Hine & Howarth J Am Chem Soc 80 2274 1958.] It has also been crystallised from CCl4, diethyl ether or EtOH [Inoue et al. J Chem Soc, Faraday Trans 1 82 523 1986]. [Beilstein 7 IV 2502.]
References
[1] N. Kanagathara. “Structural and Vibrational Investigation of Benzil-(1,2-Diphenylethane-1,2-Dione): Experimental and Theoretical Studies.” New Journal of Chemistry 3 1 (2022).
Benzil Preparation Products And Raw materials
Raw materials
Preparation Products
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| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| PERFECT CHEMICAL | +91-9820465461 +91-9820465461 | Mumbai, India | 391 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| Orgamine Chemicals(I) Pvt Ltd | +91-9820080281 +91-9820080281 | Maharashtra, India | 451 | 58 | Inquiry |
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| G C Int'L | 91-22-40850400 | Maharashtra, India | 125 | 58 | Inquiry |
| Brisben Chemicals | 08048963750 | Mumbai, India | 509 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Bridge Chem Pvt., Ltd. | 91-22-66611488 | Mumbai, India | 128 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| PERFECT CHEMICAL | 58 |
| JSK Chemicals | 58 |
| Macleods Pharmaceuticals Limited | 58 |
| Orgamine Chemicals(I) Pvt Ltd | 58 |
| Navone Specialties (OPC) Pvt Ltd | 58 |
| G C Int'L | 58 |
| Brisben Chemicals | 58 |
| Anand Agencies | 58 |
| Bridge Chem Pvt., Ltd. | 58 |
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