Tocoretinate
- CAS No.
- 40516-48-1
- Chemical Name:
- Tocoretinate
- Synonyms
- N 021;L 300;Olcenon;TOCORETINATE;tretinoin tocoferil;dl-α-Tocopheryl Retinoate;dl-a-Tocopheryl Retinoate;VITAMIN E VITAMIN A ACID ESTER;Retinoic acid, (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl ester, (±)-;Retinoic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester, [2R*(4R*,8R*)]-(+-)-
- CBNumber:
- CB8700933
- Molecular Formula:
- C49H76O3
- Molecular Weight:
- 713.13
- MOL File:
- 40516-48-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/14 17:37:00
| Boiling point | 761.3±60.0 °C(Predicted) |
|---|---|
| Density | 0.959±0.06 g/cm3(Predicted) |
| CAS DataBase Reference | 40516-48-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice (mg/kg): >1000 i.v.; >2000 orally (Fukawa, 1975) |
|---|
Tocoretinate Chemical Properties,Uses,Production
Description
Tretinoin tocoferil, the a-tocopherol ester of all-trans-retinoic acid, was launched for the treatment of bedsores and skin ulcers such as burn, leg, and diabetic ulcers. It is also an orally active agent for gastric ulcer treatment. Tretinoin tocoferil represents a new class of antiulcer drugs which act by directly promoting tissue repair, distinguished from common drugs that exert an indirect function by suppression of acid-secretion and mucosa protection. The mode of its action has been proposed to relate to its ability to stimulate DNA synthesis of growth-arrested human skin fibroblasts by promoting expression of the epidermal growth factor receptor.
Uses
dl-α-Tocopheryl Retinoate is an α-tocopherol ester of all-trans retinoic acid (R250200) and is safely used in the treatment of skin ulcer. ?dl-α-Tocopheryl Retinoate inhibited proliferation of human promyelocytic leukemia HL-60 cells and induced granulocytic differentiation of the cells, but to a lesser extent than did retinoic acid.
Tocoretinate Preparation Products And Raw materials
Raw materials
Preparation Products
Tocoretinate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Horster Biotek Pvt Ltd | +91-7359657360 +91-9898127219 | Gujarat, India | 58 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | China | 9959 | 58 | Inquiry |