L371,257

CAS No.: 162042-44-6

Chemical Name:: L371,257

Synonyms: 257;L-371;L371,257;L371,257,L 371,257;1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one;1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine;2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-

CBNumber:: CB8850593

Molecular Formula:: C28H33N3O6

Molecular Weight:: 507.58

MOL File:: 162042-44-6.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:39

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L371,257 Properties

Boiling point	728.9±60.0 °C(Predicted)
Density	1.282±0.06 g/cm3(Predicted)
storage temp.	Store at RT
solubility	Soluble to 10 mM in DMSO with gentle warming
form	Powder
pka	0.73±0.20(Predicted)
color	White to off-white

L371,257 Chemical Properties,Uses,Production

Uses

L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats.

Biological Activity

Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.

L371,257 Preparation Products And Raw materials

Raw materials

Preparation Products

L371,257 Suppliers

Global( 31)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd.	+86-18521732826	China	48467	58	Inquiry
Suzhou Haiben Pharmaceutical Co., Ltd	14760821013 14760821013	China	5417	58	Inquiry
https://hanhongsci.com/	021-54306202 18917919676	China	29990	58	Inquiry
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	China	18488	58	Inquiry
Hebei Weite Medical Technology Co., Ltd	13180081292	China	7322	58	Inquiry
Nantong Hi-Future Biotechnology Co., Ltd	18051384581	China	3059	58	Inquiry

Supplier	Advantage
TargetMol Chemicals Inc.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58
Suzhou Haiben Pharmaceutical Co., Ltd	58
https://hanhongsci.com/	58
Changzhou Bojia Biomedical Technology Co., Ltd.	58
Hebei Weite Medical Technology Co., Ltd	58
Nantong Hi-Future Biotechnology Co., Ltd	58

L371,257 Spectrum

L371,257(162042-44-6)¹HNMR

162042-44-6(L371,257)Related Search:

4-Cbz-Aminopiperidine 1-Acetyl-4-(methylamino)piperidine 4-Methoxysalicylamide 4-(4-METHYLPHENOXY)PIPERIDINE HYDROCHLORIDE 4-PHENOXYPIPERIDINE

4-[3-(Dimethylamino)propoxy]benzaldehyde 1-(4-ISOPROPOXYPHENYL)METHANAMINE 2,4-Dihydroxybenzamide 4-ANILINO-1-BENZYLPIPERIDINE 4-(3-METHOXYPHENOXY)PIPERIDINE

1-Acetylpiperidin-4-amine 4-(PIPERIDIN-4-YLOXY)BENZAMIDE (4-AMINO-PIPERIDIN-1-YL)-PHENYL-METHANONE Benzamide, N-(3-dimethylaminopropyl)-p-propoxy- 4-ETHOXY-N,N-DIETHYLBENZAMIDE

CHEMBRDG-BB 9072047 4-AMINOCARBETHOXYPIPERIDINE 1-ACETYLPIPERIDIN-4-OL

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L371,257 1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine 1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one 2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro- 257 L-371 L371,257,L 371,257 162042-44-6 C28H33N3O6