Actinomycin D
- CAS No.
- 50-76-0
- Chemical Name:
- Actinomycin D
- Synonyms
- ad;DACTINOMYCIN;cosmegen;CACTINOMYCIN;actd;acto-d;nsc3053;AD(VAN);CS-2273;Cosmogen
- CBNumber:
- CB8853701
- Molecular Formula:
- C62H86N12O16
- Molecular Weight:
- 1255.42
- MOL File:
- 50-76-0.mol
- Modify Date:
- 2023/9/4 17:31:24
| Melting point | 251-253 °C |
|---|---|
| Boiling point | 848°C (rough estimate) |
| Density | 1.0757 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| Flash point | 87℃ |
| storage temp. | 2-8°C |
| solubility | ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble |
| pka | 8.94±0.70(Predicted) |
| form | powder |
| color | red, powder |
| optical activity | [α]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol)) |
| Water Solubility | SOLUBLE |
| Merck | 13,2828 |
| BRN | 605235 |
| Stability | Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible. |
| CAS DataBase Reference | 50-76-0(CAS DataBase Reference) |
| IARC | 3 (Vol. 10, Sup 7) 1987 |
| EPA Substance Registry System | Actinomycin D (50-76-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H350-H360FD | |||||||||
| Precautionary statements | P201-P202-P264-P270-P280-P301+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28-61-40-45-26/27/28 | |||||||||
| Safety Statements | 53-36/37/39-45-1-36/37-28-22 | |||||||||
| RIDADR | UN 3462 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AU1575000 | |||||||||
| F | 8-10-21 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29419000 | |||||||||
| Toxicity | LD50 oral in rat: 7200ug/kg | |||||||||
| NFPA 704 |
|
Actinomycin D price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A9415 | Actinomycin D from Streptomyces sp., suitable for cell culture, ≥95% | 50-76-0 | 2MG | ₹7772.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A9415 | Actinomycin D from Streptomyces sp., suitable for cell culture, ≥95% | 50-76-0 | 5MG | ₹17785.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A9415 | Actinomycin D from Streptomyces sp., suitable for cell culture, ≥95% | 50-76-0 | 10MG | ₹34704.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SBR00013 | Actinomycin D, Ready Made Solution from Streptomyces sp., 2?mg/mL in DMSO | 50-76-0 | 1ML | ₹15388.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A9415 | Actinomycin D from Streptomyces sp., suitable for cell culture, ≥95% | 50-76-0 | 25MG | ₹54103.35 | 2022-06-14 | Buy |
Actinomycin D Chemical Properties,Uses,Production
Chemical Properties
Actinomycin D is a combustible, bright red crystalline solid.
Uses
Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumour activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumour cell death has been demonstrated to occur by apoptosis.
Indications
Dactinomycin (actinomycin D, Cosmegen) is one of a family of chromopeptides produced by Streptomyces. It is known to bind noncovalently to double-strand DNA by partial intercalation, inhibiting DNA-directed RNA synthesis. The drug is most toxic to proliferating cells, but it is not specific for any one phase of the cell cycle. Resistance to dactinomycin is caused by decreased ability of tumor cells to take up and retain the drug, and it is associated with cross-resistance to vinca alkaloids, the anthracyclines, and certain other agents (multidrug resistance).
General Description
Bright red rhomboid prisms or red powder.
Air & Water Reactions
Water soluble.
Reactivity Profile
Actinomycin D can react with strong oxidizing agents, strong acids and strong bases.
Fire Hazard
Flash point data for Actinomycin D are not available. Actinomycin D is probably combustible.
Biological Activity
Anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.
Mechanism of action
Dactinomycin is cleared rapidly from plasma, does not enter the brain, is not appreciably metabolized or protein bound, and is gradually excreted in both bile and urine.Virtually no drug is detected in CSF.
Clinical Use
Dactinomycin is used in curative combined treatment of Wilms’ tumor, Ewing’s sarcoma, rhabdomyosarcoma, and gestational choriocarcinoma. It is active in testicular tumors, lymphomas, melanomas, and sarcomas, although its use in most of these malignancies has been supplanted by other agents.
Side effects
The major side effects of dactinomycin are severe nausea, vomiting, and myelosuppression. Mucositis, diarrhea, alopecia, and radiation recall reactions may occur. The drug is immunosuppressive and carcinogenic.
Potential Exposure
An antibiotic product from streptomyces, used as anticancer and veterinary drug
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
It crystallises as bright red rhombic crystals from absolute EtOH or from MeOH/EtOH (1:3). It will also crystallise from EtOAc/cyclohexane (m 246-247o dec), CHCl3/pet ether ( m 245-246o dec), and EtOAc/MeOH/*C6H6 (m 241-243o dec). Its solubility in MeCN is 1mg/mL. [] D varies from -296o to -327o (c 0.2, MeOH). max (MeOH) 445, 240nm (log 4.43, 4.49), max (MeOH, 10N HCl, 1:1) 477nm (log 4.21) and max (MeOH, 0.1N NaOH) 458, 344, 285 (log 3.05, 4.28, 4.13). It is HIGHLY TOXIC, light sensitive and anti-neoplastic. [Bullock & Johnson, J Chem Soc 3280 1957, Beilstein 27 III/IV 9642.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Actinomycin D Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Concord Biotech Limited | +91-2714398200 +91-2714398200 | Gujarat, India | 22 | 58 | Inquiry |
| Euroasia Trans Continental | +91 22 56349035-36 | New Delhi, India | 519 | 47 | Inquiry |
| CONCORD BIOTECH LTD | +91 79 68138700 | New Delhi, India | 18 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Medicea Impex Private Limited | 07942544983 | Nagpur, India | 24 | 58 | Inquiry |
50-76-0(Actinomycin D)Related Search:
1of4
chevron_right