ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >trans-4-Dimethylaminocrotonic acid hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride
- CAS No.
- 848133-35-7
- Chemical Name:
- trans-4-Dimethylaminocrotonic acid hydrochloride
- Synonyms
- (E)-4-(dimethylamino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;THRX-196194;Afatinib intermediate E;trans-4-Dimethylaminocrotonic;(E)-4-(Dimethylamino)-2-buteno;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL;(2E)-4-(Dimethylamino)but-2-enoic acid HCl
- CBNumber:
- CB8854829
- Molecular Formula:
- C6H12ClNO2
- Molecular Weight:
- 165.62
- MOL File:
- 848133-35-7.mol
- Modify Date:
- 2024/5/16 17:35:26
| Melting point | 162 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+; |
| InChIKey | UUHNQHFOIVLAQX-BJILWQEISA-N |
| SMILES | C(/CN(C)C)=C\C(=O)O.Cl |
| CAS DataBase Reference | 848133-35-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| HS Code | 2922498590 | |||||||||
| NFPA 704 |
|
trans-4-Dimethylaminocrotonic acid hydrochloride price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | D5625 | (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride | 848133-35-7 | 1G | ₹3200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D5625 | (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride | 848133-35-7 | 5G | ₹10800 | 2022-05-26 | Buy |
trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties,Uses,Production
Description
trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.
Chemical Properties
White Solid
Uses
trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.
Synthesis
trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.
trans-4-Dimethylaminocrotonic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 379)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ergam Life Sciences Pvt. Ltd. | +91-8125300959 +91-08125300959 | Telangana, India | 68 | 58 | Inquiry |
| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| Vibrant Life Sciences | +917989177519 | Telangana, India | 26 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Vignasai Laboratories Private Limited | 08068442228Ext 516 | Hyderabad, India | 35 | 58 | Inquiry |
| Akshaya Pure Chemicals | 08048372572Ext 130 | Mumbai, India | 36 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
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2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride
Afatinib int-2 Trans-4-Dimethylaminocrotonic acid hydrochloride
2-Butenoic acid, 4-(dimethylamino)-, (2E)-, hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride, >=97%
trans-4-Dimethylaminocrotonic
trans-4-dimethylaminocrotonic acid hydrochloride salt
4-DiMethylaMino-But-2-Enoic Acid Hcl Salt
trans-4-Dimethylaminocrotonic acid hydrochloride
TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL
2-BUTENOIC ACID, 4-(DIMETHYLAMINO)-, HYDROCHLORIDE
Afatinib intermediate E
(2E)-4-(diMethylaMino)but-2-enoic acid hydrochloride
trans-4-(DiMethylaMino)-2-butenoic Acid Hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride (E)-4-(Dimethylamino)-2-butenoic acid hydrochloride
2-Butenoic acid,4-(dimethylamino)-, hydrochloride (1:1), (2E)-
trans-4-Dimethylaminocrotonic acid hydrochloride(848133-35-7)
(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL
(2E)-4-(dimethylamino)but-2-enoic acid hydrochloride, trans
2-Butenoic acid, 4-(dimethylamino)-, hydrochloride (1:1)
(2E)-4-(Dimethylamino)but-2-enoic acid?hydrochloride (1:1)
(E)-4-Dimethylaminocrotonic Acid Hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride ISO 9001：2015 REACH
(e)-4-(dimethylamino)-2-butenoic acid hydrochloride
(E)-4-(dimethylamino)but-2-enoic acid hydrochloride
THRX-196194
(E)-4-(Dimethylamino)-2-buteno
(2E)-4-(dimethylamino)-2-Butenoic acid hydrochloride (1:1)
(2E)-4-(Dimethylamino)but-2-enoic acid HCl
trans-4-Dimethylaminocrotonic acid hydrochloride，(E)-4-(Dimethylamino)But-2-Enoic Acid Hydrochloride
848133-35-7
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848133-35-7