4-bromo-2,5-difluorobenzoic acid
- CAS No.
- 28314-82-1
- Chemical Name:
- 4-bromo-2,5-difluorobenzoic acid
- Synonyms
- 4-bromo-2,5-difluorobenzoic acid;2,5-Difluoro-4-broMobenzoic acid;Benzoic acid, 4-broMo-2,5-difluoro-;2-Propenoicacid,2-cyano-3-phenyl-,methylester,(5E)-;4-bromo-2,5-difluorobenzoic acid ISO 9001：2015 REACH
- CBNumber:
- CB91559384
- Molecular Formula:
- C7H3BrF2O2
- Molecular Weight:
- 237
- MOL File:
- 28314-82-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/24 17:21:45
| Boiling point | 285.0±40.0 °C(Predicted) |
|---|---|
| Density | 1.872±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 2.70±0.10(Predicted) |
| form | wooly powder |
| color | Creamy peach |
| InChI | InChI=1S/C7H3BrF2O2/c8-4-2-5(9)3(7(11)12)1-6(4)10/h1-2H,(H,11,12) |
| InChIKey | YWZSTHLOAZTDFJ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(F)=C(Br)C=C1F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P301+P310 |
| HS Code | 2916399090 |
4-bromo-2,5-difluorobenzoic acid Chemical Properties,Uses,Production
Uses
4-Bromo-2,5-difluorobenzoic acid is a synthetic chemical compound that is widely used in scientific research. It is a versatile compound that can be used in many different laboratory experiments. It is also a fluorinated benzoic acid derivative and can be used as a reagent in a variety of organic and inorganic reactions.
Synthesis
Freshly titrated n-butyl lithium (27.0 ml, 1.39 M in hexanes) is added slowly (over about 30 minutes) to a -78°C solution of diethyl ether (90 ml) containing 1,4-dibromo-2,5-difluorobenzene (10.22 g, 0.038 mol). The resulting yellow solution is stirred at -78°C for 2 hours to give a yellow suspension. Several pellets (~10) of dry ice are added to the suspension, which is then allowed to warm slowly to room temperature as it degasses (approximately 40 minutes). The resulting suspension is acidified with a 1 M aqueous solution of hydrochloric acid (500 ml), and the product extracted with diethyl ether (5 x 200 ml). The combined organics are washed with water (4 x 100 ml) and filtered. The ether solution is concentrated to approximately 200 ml under reduced pressure, and the product extracted into a saturated aqueous solution of sodium bicarbonate (3 x 200 ml). The combined aqueous extracts are washed with methylene chloride (3 x 100 ml) and acidified with hydrochloric acid. The product is extracted with diethyl ether (3 x 200 ml), and the combined organic extracts washed with water (2 x 200 ml), dried over magnesium sulfate, and concentrated under reduced pressure to give 4-Bromo-2,5-difluorobenzoic acid as a pale yellow solid.
Figure Synthesis of 4-Bromo-2,5-difluorobenzoic acid
4-bromo-2,5-difluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | China | 4226 | 58 | Inquiry |
| Shanghai Scochem Technology Co., Ltd | +86-021-33758897 +86-13701882790 | China | 1977 | 58 | Inquiry |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +86-86177 | China | 2901 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | China | 1377 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | China | 788 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | China | 8826 | 58 | Inquiry |
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