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Fmoc-L-glutamic acid 5-tert-butyl ester

Fmoc-L-glutamic acid 5-tert-butyl ester Structure
CAS No.
71989-18-9
Chemical Name:
Fmoc-L-glutamic acid 5-tert-butyl ester
Synonyms
FMOC-GLU(OTBU)-OH;(S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-5-(tert-butoxy)-5-oxopentanoic acid;FMOC-GLU(TBU)-OH;FMOC-L-GLU(OTBU)-OH;FMOC-L-GLU(TBU)-OH;Fomc-Glu(OtBu)-OH;5-tert-Butyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamate Hydrate;Fomc-Glu(O;u(OtBu)-OH;cas:71989-18-9
CBNumber:
CB9161890
Molecular Formula:
C24H27NO6
Molecular Weight:
425.47
MOL File:
71989-18-9.mol
Modify Date:
2023/11/27 16:20:28

Fmoc-L-glutamic acid 5-tert-butyl ester Properties

Melting point 83-90 °C
alpha -4.5 º (c=1, 80% acetic acid)
Boiling point 633.5±55.0 °C(Predicted)
Density 1.232±0.06 g/cm3(Predicted)
refractive index -4 ° (C=1, 80% AcOH)
storage temp. Store below +30°C.
solubility soluble in Methanol
form powder to crystal
pka 3.70±0.10(Predicted)
color White to Almost white
optical activity [α]20/D 5.0±2.0°, c = 1% in acetic acid: water (4:1)
BRN 3636375
InChIKey OTKXCALUHMPIGM-FQEVSTJZSA-N
SMILES C(O)(=O)[C@H](CCC(OC(C)(C)C)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference 71989-18-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H311-H331
Precautionary statements  P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-27-36/37/39-24/25
WGK Germany  3
HS Code  2924 29 70
NFPA 704
0
0 0

Fmoc-L-glutamic acid 5-tert-butyl ester price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 8.52009 Fmoc-Glu(OtBu)-OH Novabiochem? 71989-18-9 25G ₹5800.01 2022-06-14 Buy
Sigma-Aldrich(India) 8.52009 Fmoc-Glu(OtBu)-OH Novabiochem? 71989-18-9 100G ₹13950 2022-06-14 Buy
Sigma-Aldrich(India) 8.52009 Fmoc-Glu(OtBu)-OH Novabiochem? 71989-18-9 250G ₹29660.01 2022-06-14 Buy
Sigma-Aldrich(India) 47625 Fmoc-Glu(OtBu)-OH ≥98.0% (HPLC) 71989-18-9 10G ₹13109.08 2022-06-14 Buy
Sigma-Aldrich 47625 Fmoc-Glu(OtBu)-OH ≥98.0% (HPLC) 71989-18-9 25G ₹19095.3 2022-06-14 Buy
Product number Packaging Price Buy
8.52009 25G ₹5800.01 Buy
8.52009 100G ₹13950 Buy
8.52009 250G ₹29660.01 Buy
47625 10G ₹13109.08 Buy
47625 25G ₹19095.3 Buy

Fmoc-L-glutamic acid 5-tert-butyl ester Chemical Properties,Uses,Production

Description

Fmoc-L-glutamic acid 5-tert-butyl ester is a Fmoc derivative with an N-substituted tert-butyl ester molecule. It is white or gray-white solid crystals at room temperature and pressure, poor solubility in water and insoluble in petroleum ether, but soluble in ethyl acetate, acetic acid and N,N-dimethylformamide.

Chemical Properties

White powder

Uses

Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a:

  • Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.
  • Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.

It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters .

General Description

The product number for this product was previously 04-12-1020.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

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N-ALPHA-FMOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER N-ALPHA-FMOC-L-GLUTAMIC ACID GAMMA-TERT-BUTYL ESTER N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-TERT-BUTYL ESTER N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GLUTAMIC-ACID-GAMMA-T-BUTYL ESTER N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-GAMMA-T-BUTYL-L-GLUTAMIC ACID N-FMOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER N-FMOC-O-T-BUTYL-L-GLU FMOC-GLU(OBUT)-OH (9-fluorenylmethoxycarbonyl)-L-glutamic acid 5-tert-butyl N-FMOC-L-glitamic acid 5-t-butyl ester 4-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) ester Nα-Fmoc-L-glutamic-acid 5-tert-butyl ester ,98% (S)-5-Oxo-5-tert-butoxy-2-[(9H-fluorene-9-ylmethoxycarbonyl)amino]pentanoic acid N-(9H-Fluorene-9-ylmethoxycarbonyl)-5-oxo-5-tert-butoxy-L-norvaline N-(9H-Fluorene-9-ylmethoxycarbonyl)-L-glutamic acid 5-tert-butyl ester N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 5-(1,1-dimethylethyl) ester 5-tert-Butyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamate Fmoc-Glutamic acid (OtBu)-OH L-GLUTAMIC ACID-N-FMOC, GAMMA-TERT-BUTYL ESTER 5-tert-Butyl N-Fmoc-L-glutamate N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic Acid 5-tert-Butyl Ester Fmoc-Glu(OtBu)-OH L-GLUTAMIC ACID, N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-GLUTAMIC ACID-5-TERT-BUTYL ESTER 5-tert-Butyl N-Fmoc-L-glutamate N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic Acid 5-tert-Butyl Ester Nα-FMoc-L-glutaMic-acid 5-tert-butyl ester Fmoc-Glu(Otbu)-OH(CAS:71989-18-9) Fmoc-Glu(OtBu)-OH Hydrate Fmoc-Glu(OtBu)-OH >=98.0% (HPLC) cas:71989-18-9 (2S)-5-tert-Butoxy-2-[[[(9H-fluoren-9-yl)Methoxy]carbonyl]aMino]-5-oxopentanoic acid FMoc-L-Glu(OBu-t)-OH N-(9-FluorenylMethoxycarbonyl)glutaMic acid γ-tert-butyl ester N-(9-FluorenylMethoxycarbonyl)-L-glutaMic acid γ-tert-butyl ester Fmoc-L-glutamic Acidγ-t-Butyl Ester FMOC-L-GLUTAMIC ACID 5-TERT-BUTYL ESTER FMOC-L-GLU(O T-BU) FMOC-L-GLU(O-T-BUTYL) FMOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER FMOC-L-GLUTAMIC ACID GAMMA-TERT-BUTYL ESTER FMOC-L-GLUTAMIC ACID G-T-BUTYL ESTER FMOC-L-GLUTAMIC ACID (OTBU) FMOC-L-GLUTAMIC ACID(O-T-BUTYL) 9-FLUORENYLMETHOXYCARBONYL-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER 5-tert-Butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-aminoglutarate FMOC-GLU(OTBU)-OH 98+% FMOC-L-GLUTAMIC ACID-O-T-BUTYLESTER MONOHYDRATE 98% Fmoc-Glu(Tbut)-Oh L-Glutamic Acid-UL-13C5,15N-N-FMOC y-t-Butyl Ester N-9-Fluorenylmethyloxycarbonyl-L-glutamicacidg-t-butylester N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GLUTAMIC-ACID-GAMMA-T-BUTYL ESTER MONOHYDRATE NALPHA-9-Fluorenylmethoxycarbonyl-L-glutamic acid GAMMA-tert- butyl ester FMOC-L-GLUTAMIC ACID GAMMA-TERT-BUTYL ESTER (FMOC-L-GLU-OTBU-OH) FMOC-L-GLU(OTBU)-OH(71989-18-9) Fomc-Glu(O N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMIC ACID (9H-Fluoren-9-yl)MethOxy]Carbonyl Glu(OtBu)-OH 5-tert-Butyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamate Hydrate>