2-chloro-5-methylpyridin-4-amine
- CAS No.
- 79055-62-2
- Chemical Name:
- 2-chloro-5-methylpyridin-4-amine
- Synonyms
- 2-Chloro-5-Methyl-pyridin-4-ylaMine;Fampridine Impurity 174;2-chloro-5-methylpyridin-4-amine;2-Chloro-5-Methyl-4-pyridinaMine;2-Chloro-4-amino-5-methylpyridine;4-aMino-2-chloro-5-Methylpyridine;4-PYRIDINAMINE, 2-CHLORO-5-METHYL-;2-Chloro-5-methyl pyridine-4-amine;2-Chloro-5-methylpyridin-4-amine98%;2-Chloro-5-methylpyridin-4-amine 98%
- CBNumber:
- CB92468371
- Molecular Formula:
- C6H7ClN2
- Molecular Weight:
- 142.59
- MOL File:
- 79055-62-2.mol
- Modify Date:
- 2024/4/29 14:28:21
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302+H312+H332-H315-H319-H335 |
Precautionary statements | P260-P280-P301+P312 |
HS Code | 2933399990 |
2-chloro-5-methylpyridin-4-amine Chemical Properties,Uses,Production
Synthesis
2-chloro-5-methylpyridin-4-amine was synthesised by reaction with 2-chloro-5-methyl-4-nitropyridine 1-oxide. The synthesis steps are as follows:
A glass pressure reactor with cross-beam stirrer was charged under argon with 29 g (153.788 mmol) of 2-chloro-5-methyl-4-nitro-1-oxidopyridin-1-ium and 2.9 g of hydrogenation catalyst (0.8% Pt and 0.6% Mo on activated carbon (D505A-105 0.8% Pt+0.6% Mo on carbon powder, BASF) and 320 ml of ethanol were added. The reactor was closed and inertized three times, each time with 3 bar argon overpressure. Hydrogenation was then carried out for 20 hours at 30℃, under a 3 bar hydrogen overpressure (conversion >98%). The reactor was inertized with argon and the reaction solution filtered through 10 g of kieselguhr. The filtrate was concentrated to dryness under reduced pressure. Yield: 23.0 g (quantitative, product still contained ethanol), purity: 97.5% (HPLC) (0051) MS (EIpos): m/z=143 [M+H]+ (0052) 1H-NMR (300 MHz, DMSO-d6): δ=1.96 (s, 3H), 6.16 (br s, 2H), 6.50 (s, 1H), 7.68 (s, 1H) In an analogous manner, a conversion of approx. 98% was achieved with a catalyst consisting of 0.8% Pt and 0.3% Mo on activated carbon. Use of 1% Pt+2% V on activated carbon achieved a conversion of approx. 87%.
2-chloro-5-methylpyridin-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
AATAMI Molecular Research Laboratories Pvt Ltd (AMRL) | +91-8985184986 +91-8148739767 | Telangana, India | 985 | 58 | Inquiry |
Clarity Research Laboratory | +91-8008229325 +91-8008229325 | Telangana, India | 96 | 58 | Inquiry |
CHATURYA BIOTECH | +91-7702707258 +91-7702707258 | Telangana, India | 479 | 58 | Inquiry |
VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
Nios laboratories | +91-9014349341 +91-8686466680 | Hyderabad, India | 59 | 58 | Inquiry |
GMFC LABS PVT LTD | +91-9133370278 +91-9133370278 | Hyderabad, India | 44 | 58 | Inquiry |
ABINTIO BIOSCIENCES | +91-6302904517 +91-7386106841 | Hyderabad, India | 301 | 58 | Inquiry |
Prodev Pharma Pvt Ltd | +91-9963029529 +91-9043422844 | Telangana, India | 102 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Supplier | Advantage |
---|---|
AATAMI Molecular Research Laboratories Pvt Ltd (AMRL) | 58 |
Clarity Research Laboratory | 58 |
CHATURYA BIOTECH | 58 |
VGS SYNTHESIS PRIVATE LIMITED | 58 |
Nios laboratories | 58 |
GMFC LABS PVT LTD | 58 |
ABINTIO BIOSCIENCES | 58 |
Prodev Pharma Pvt Ltd | 58 |
A.J Chemicals | 58 |
CLEARSYNTH LABS LTD. | 58 |